FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567904103> ?p ?o ?g. }

• W1567904103 endingPage "4121" @default.
• W1567904103 startingPage "4116" @default.
• W1567904103 abstract "Data from numerous laboratories show that mitochondria isolated from livers treated acutely with glucagon have higher rates of state 3 respiration than control mitochondria. The purpose of the present study was to learn whether this phenomenon is an isolation artifact resulting from a stabilization of the mitochondrial membrane or whether it represents a real increase in the maximal respiratory capacity of liver cells due to glucagon treatment. Electron transport was measured through different spans of the electron transport chain by using ferricyanide as an alternate electron acceptor to O2. With isolated intact liver mitochondria, pretreatment with glucagon was found to cause an increase in electron flow, through both Complex I and Complex III, suggesting that the effect of glucagon was not specific for a single site in the electron transport chain. Using intact isolated hepatocytes, different results are obtained. Respiration was measured in isolated hepatocytes after quantitation of the hepatocyte mitochondrial content by assay of citrate synthase. Hepatocyte respiration could therefore be reported per mg of mitochondrial protein. By providing durohydroquinone to the cells, it was possible to measure electron flow from coenzyme Q to O2 in the absence of the physiological regulation of substrate supply. Likewise, the addition of carbonyl cyanide p-trifluoromethoxyphenylhydrazone released the in situ mitochondria from control by the cytosolic ATP/ADP ratio and it was possible to measure maximal electron flow rates through Complex III. In the presence of carbonyl cyanide p-trifluoromethoxyphenylhydrazone, electron flow was higher in mitochondria in the cell than in isolated mitochondria. Glucagon caused no increase in mitochondrial respiration in situ either in the presence of the physiological substrates or in the presence of durohydroquinone. The data obtained do not support a role for the electron transport chain as a target of glucagon action in hepatocytes." @default.
• W1567904103 created "2016-06-24" @default.
• W1567904103 creator A5001128846 @default.
• W1567904103 creator A5035377296 @default.
• W1567904103 creator A5085542208 @default.
• W1567904103 date "1984-04-01" @default.
• W1567904103 modified "2023-09-29" @default.
• W1567904103 title "The effect of glucagon on hepatic respiratory capacity." @default.
• W1567904103 cites W1237786724 @default.
• W1567904103 cites W1428017233 @default.
• W1567904103 cites W1480079789 @default.
• W1567904103 cites W1490099111 @default.
• W1567904103 cites W1496379136 @default.
• W1567904103 cites W1498264766 @default.
• W1567904103 cites W1522261519 @default.
• W1567904103 cites W1533501177 @default.
• W1567904103 cites W1541508612 @default.
• W1567904103 cites W1591591358 @default.
• W1567904103 cites W1770928746 @default.
• W1567904103 cites W1830931920 @default.
• W1567904103 cites W193452758 @default.
• W1567904103 cites W1957691535 @default.
• W1567904103 cites W1971557450 @default.
• W1567904103 cites W1974203440 @default.
• W1567904103 cites W198505879 @default.
• W1567904103 cites W1998454540 @default.
• W1567904103 cites W2004148053 @default.
• W1567904103 cites W2014132288 @default.
• W1567904103 cites W2030726591 @default.
• W1567904103 cites W2032157645 @default.
• W1567904103 cites W2057370136 @default.
• W1567904103 cites W2063313193 @default.
• W1567904103 cites W2065218660 @default.
• W1567904103 cites W2081642682 @default.
• W1567904103 cites W2086443149 @default.
• W1567904103 cites W2153334627 @default.
• W1567904103 cites W2183344455 @default.
• W1567904103 cites W2204387847 @default.
• W1567904103 cites W223224459 @default.
• W1567904103 cites W2319677659 @default.
• W1567904103 cites W2345011142 @default.
• W1567904103 cites W2402371779 @default.
• W1567904103 cites W40321290 @default.
• W1567904103 doi "https://doi.org/10.1016/s0021-9258(17)43017-1" @default.
• W1567904103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6706994" @default.
• W1567904103 hasPublicationYear "1984" @default.
• W1567904103 type Work @default.
• W1567904103 sameAs 1567904103 @default.
• W1567904103 citedByCount "35" @default.
• W1567904103 countsByYear W15679041032019 @default.
• W1567904103 countsByYear W15679041032022 @default.
• W1567904103 crossrefType "journal-article" @default.
• W1567904103 hasAuthorship W1567904103A5001128846 @default.
• W1567904103 hasAuthorship W1567904103A5035377296 @default.
• W1567904103 hasAuthorship W1567904103A5085542208 @default.
• W1567904103 hasBestOaLocation W15679041031 @default.
• W1567904103 hasConcept C126322002 @default.
• W1567904103 hasConcept C134018914 @default.
• W1567904103 hasConcept C185592680 @default.
• W1567904103 hasConcept C2778563252 @default.
• W1567904103 hasConcept C2779306644 @default.
• W1567904103 hasConcept C534529494 @default.
• W1567904103 hasConcept C71924100 @default.
• W1567904103 hasConceptScore W1567904103C126322002 @default.
• W1567904103 hasConceptScore W1567904103C134018914 @default.
• W1567904103 hasConceptScore W1567904103C185592680 @default.
• W1567904103 hasConceptScore W1567904103C2778563252 @default.
• W1567904103 hasConceptScore W1567904103C2779306644 @default.
• W1567904103 hasConceptScore W1567904103C534529494 @default.
• W1567904103 hasConceptScore W1567904103C71924100 @default.
• W1567904103 hasIssue "7" @default.
• W1567904103 hasLocation W15679041031 @default.
• W1567904103 hasOpenAccess W1567904103 @default.
• W1567904103 hasPrimaryLocation W15679041031 @default.
• W1567904103 hasRelatedWork W1987976051 @default.
• W1567904103 hasRelatedWork W2033052007 @default.
• W1567904103 hasRelatedWork W2067188704 @default.
• W1567904103 hasRelatedWork W2070046754 @default.
• W1567904103 hasRelatedWork W2073527559 @default.
• W1567904103 hasRelatedWork W2092767995 @default.
• W1567904103 hasRelatedWork W2145722810 @default.
• W1567904103 hasRelatedWork W2157523186 @default.
• W1567904103 hasRelatedWork W2331234043 @default.
• W1567904103 hasRelatedWork W2748952813 @default.
• W1567904103 hasVolume "259" @default.
• W1567904103 isParatext "false" @default.
• W1567904103 isRetracted "false" @default.
• W1567904103 magId "1567904103" @default.
• W1567904103 workType "article" @default.