Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567931242> ?p ?o ?g. }
- W1567931242 endingPage "R42" @default.
- W1567931242 startingPage "R42" @default.
- W1567931242 abstract "Antimalarial agents have been widely used as disease-modifying antirheumatic drugs in the treatment of systemic lupus erythematosus (SLE) and other rheumatological diseases, although their mechanism of action has not yet been fully defined. It is known, however, that effective response to treatment is variable among patients. Thus, the identification of genetic predictors of treatment response would provide valuable information for therapeutic intervention. The aim of the present study was to analyze the effect of antimalarial treatment on tumor necrosis factor (TNF)alpha serum levels and evaluate the possible influence of TNFalpha and IL-10 functional genetic polymorphisms on the response to antimalarial drugs. To this end, TNFalpha serum levels were quantified in 171 SLE patients and 215 healthy controls by ELISA techniques and polymorphisms at positions -1,082 and -308 of the IL-10 and TNFalpha gene promoters were determined by PCR amplification followed by hybridization with fluorescent-labeled allele-specific probes in 192 SLE patients and 343 matched controls. Data were related to clinical features and treatment at the time of sampling and during the course of the disease. Results showed a significantly higher amount of serum TNFalpha in the entire SLE population compared with controls. However, TNFalpha serum levels correlated negatively with the use of antimalarial treatment during at least three months before sampling. Patients under single or combined treatment with these drugs had TNFalpha serum levels similar to healthy controls, whereas untreated patients and those under corticosteroid or immunosuppressive therapies had increased amounts of this cytokine. This suggests, however, that antimalarial-mediated inhibition of TNFalpha was only significant in patients who were genetically high TNFalpha or low IL-10 producers. In addition, evaluation of SLE patients administered antimalarial drugs for three or more years who did not require any other specific SLE treatment indicates that patients with the combined genotype low IL-10/high TNFalpha are the best responders to antimalarial therapy, developing mild disease with a good course under this treatment. In conclusion, we proposed that an antimalarial-mediated downregulation of TNFalpha levels in SLE patients is influenced by polymorphisms at IL-10 and TNFalpha promoters. Our results may thus find important clinical application through the identification of patients who are the most likely to benefit from antimalarial therapy." @default.
- W1567931242 created "2016-06-24" @default.
- W1567931242 creator A5003007509 @default.
- W1567931242 creator A5016527076 @default.
- W1567931242 creator A5034671166 @default.
- W1567931242 creator A5083176651 @default.
- W1567931242 creator A5089633340 @default.
- W1567931242 date "2006-01-01" @default.
- W1567931242 modified "2023-10-08" @default.
- W1567931242 cites W1589670817 @default.
- W1567931242 cites W1925208150 @default.
- W1567931242 cites W1968720144 @default.
- W1567931242 cites W1971836284 @default.
- W1567931242 cites W1974003531 @default.
- W1567931242 cites W1985763670 @default.
- W1567931242 cites W1990097603 @default.
- W1567931242 cites W1997773350 @default.
- W1567931242 cites W1997856540 @default.
- W1567931242 cites W2002102442 @default.
- W1567931242 cites W2006529026 @default.
- W1567931242 cites W2006619058 @default.
- W1567931242 cites W2008489937 @default.
- W1567931242 cites W2013093849 @default.
- W1567931242 cites W2023102754 @default.
- W1567931242 cites W2026775625 @default.
- W1567931242 cites W2054327643 @default.
- W1567931242 cites W2059208362 @default.
- W1567931242 cites W2061542205 @default.
- W1567931242 cites W2063809930 @default.
- W1567931242 cites W2072681359 @default.
- W1567931242 cites W2080147816 @default.
- W1567931242 cites W2086751610 @default.
- W1567931242 cites W2088391727 @default.
- W1567931242 cites W2095998776 @default.
- W1567931242 cites W2122833930 @default.
- W1567931242 cites W2133422071 @default.
- W1567931242 cites W2134122064 @default.
- W1567931242 cites W2146203649 @default.
- W1567931242 cites W2151014311 @default.
- W1567931242 cites W2162286513 @default.
- W1567931242 cites W2171655564 @default.
- W1567931242 cites W2172108014 @default.
- W1567931242 cites W2404058904 @default.
- W1567931242 doi "https://doi.org/10.1186/ar1897" @default.
- W1567931242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1526590" @default.
- W1567931242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16507146" @default.
- W1567931242 hasPublicationYear "2006" @default.
- W1567931242 type Work @default.
- W1567931242 sameAs 1567931242 @default.
- W1567931242 citedByCount "31" @default.
- W1567931242 countsByYear W15679312422012 @default.
- W1567931242 countsByYear W15679312422013 @default.
- W1567931242 countsByYear W15679312422014 @default.
- W1567931242 countsByYear W15679312422015 @default.
- W1567931242 countsByYear W15679312422016 @default.
- W1567931242 countsByYear W15679312422017 @default.
- W1567931242 countsByYear W15679312422019 @default.
- W1567931242 countsByYear W15679312422020 @default.
- W1567931242 countsByYear W15679312422021 @default.
- W1567931242 countsByYear W15679312422022 @default.
- W1567931242 crossrefType "journal-article" @default.
- W1567931242 hasAuthorship W1567931242A5003007509 @default.
- W1567931242 hasAuthorship W1567931242A5016527076 @default.
- W1567931242 hasAuthorship W1567931242A5034671166 @default.
- W1567931242 hasAuthorship W1567931242A5083176651 @default.
- W1567931242 hasAuthorship W1567931242A5089633340 @default.
- W1567931242 hasBestOaLocation W15679312421 @default.
- W1567931242 hasConcept C126322002 @default.
- W1567931242 hasConcept C17991360 @default.
- W1567931242 hasConcept C198451711 @default.
- W1567931242 hasConcept C203014093 @default.
- W1567931242 hasConcept C2779134260 @default.
- W1567931242 hasConcept C2908647359 @default.
- W1567931242 hasConcept C71924100 @default.
- W1567931242 hasConcept C98274493 @default.
- W1567931242 hasConcept C99454951 @default.
- W1567931242 hasConceptScore W1567931242C126322002 @default.
- W1567931242 hasConceptScore W1567931242C17991360 @default.
- W1567931242 hasConceptScore W1567931242C198451711 @default.
- W1567931242 hasConceptScore W1567931242C203014093 @default.
- W1567931242 hasConceptScore W1567931242C2779134260 @default.
- W1567931242 hasConceptScore W1567931242C2908647359 @default.
- W1567931242 hasConceptScore W1567931242C71924100 @default.
- W1567931242 hasConceptScore W1567931242C98274493 @default.
- W1567931242 hasConceptScore W1567931242C99454951 @default.
- W1567931242 hasIssue "2" @default.
- W1567931242 hasLocation W15679312421 @default.
- W1567931242 hasLocation W15679312422 @default.
- W1567931242 hasLocation W15679312423 @default.
- W1567931242 hasLocation W15679312424 @default.
- W1567931242 hasOpenAccess W1567931242 @default.
- W1567931242 hasPrimaryLocation W15679312421 @default.
- W1567931242 hasRelatedWork W1977918131 @default.
- W1567931242 hasRelatedWork W1990717759 @default.
- W1567931242 hasRelatedWork W2082482010 @default.
- W1567931242 hasRelatedWork W2151614054 @default.
- W1567931242 hasRelatedWork W2287752887 @default.
- W1567931242 hasRelatedWork W2622204852 @default.