Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567932233> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1567932233 abstract "Intraperitoneal injection of lipopolysaccharide (LPS) is a common method to induce systemic inflammation, but there is wide variability in the doses given and no standardized measure of inflammatory level. We characterized the inflammatory response in adult male and female C57BL/6 mice following 3 LPS exposure protocols by measuring body weight changes, spleen weight and immune cell composition in the blood using flow cytometry. Mice were injected twice a week for 1 month with either a 200 μL dose of saline or a low dose of LPS (7.5 x 10^4 EU/kg). Half the animals in each condition were injected with a high dose of LPS (7.5 X 10^5 EU/kg) the day before sacrifice. Acute exposure to a high dose of LPS caused a 10.6% decrease in body weight overnight and no significant change in spleen weight. White blood cell and lymphocyte counts decreased and toll-like receptor 4 (TLR4) positive macrophage count increased for both males and females. Exposure to 1 month of low LPS caused no change in the immune cell composition in the blood and body weight, but spleen weights were significantly increased compared to saline animals. 1 month of low LPS followed by high LPS caused an even greater increase in spleen weight than the 1 month low LPS condition, but no other changes. In summary, all 3 LPS exposure protocols led to evidence of an immune response in both sexes, but body weight and blood immune cell composition normalized following chronic low LPS exposure. Grant Funding Source: Supported by a CSUPERB New Investigator Award (KAW)" @default.
- W1567932233 created "2016-06-24" @default.
- W1567932233 creator A5005570002 @default.
- W1567932233 creator A5042163149 @default.
- W1567932233 creator A5042574025 @default.
- W1567932233 creator A5063913161 @default.
- W1567932233 creator A5089731628 @default.
- W1567932233 date "2014-04-01" @default.
- W1567932233 modified "2023-09-27" @default.
- W1567932233 title "Characterization of the immune response in male and female mice following lipopolysaccharide‐induced systemic inflammation (1096.10)" @default.
- W1567932233 doi "https://doi.org/10.1096/fasebj.28.1_supplement.1096.10" @default.
- W1567932233 hasPublicationYear "2014" @default.
- W1567932233 type Work @default.
- W1567932233 sameAs 1567932233 @default.
- W1567932233 citedByCount "4" @default.
- W1567932233 countsByYear W15679322332017 @default.
- W1567932233 countsByYear W15679322332021 @default.
- W1567932233 countsByYear W15679322332022 @default.
- W1567932233 crossrefType "journal-article" @default.
- W1567932233 hasAuthorship W1567932233A5005570002 @default.
- W1567932233 hasAuthorship W1567932233A5042163149 @default.
- W1567932233 hasAuthorship W1567932233A5042574025 @default.
- W1567932233 hasAuthorship W1567932233A5063913161 @default.
- W1567932233 hasAuthorship W1567932233A5089731628 @default.
- W1567932233 hasConcept C126322002 @default.
- W1567932233 hasConcept C134018914 @default.
- W1567932233 hasConcept C189976730 @default.
- W1567932233 hasConcept C203014093 @default.
- W1567932233 hasConcept C2776070231 @default.
- W1567932233 hasConcept C2776252253 @default.
- W1567932233 hasConcept C2776914184 @default.
- W1567932233 hasConcept C2777397205 @default.
- W1567932233 hasConcept C2777761686 @default.
- W1567932233 hasConcept C2778488018 @default.
- W1567932233 hasConcept C2778754761 @default.
- W1567932233 hasConcept C2780159080 @default.
- W1567932233 hasConcept C2780931953 @default.
- W1567932233 hasConcept C71924100 @default.
- W1567932233 hasConcept C8891405 @default.
- W1567932233 hasConceptScore W1567932233C126322002 @default.
- W1567932233 hasConceptScore W1567932233C134018914 @default.
- W1567932233 hasConceptScore W1567932233C189976730 @default.
- W1567932233 hasConceptScore W1567932233C203014093 @default.
- W1567932233 hasConceptScore W1567932233C2776070231 @default.
- W1567932233 hasConceptScore W1567932233C2776252253 @default.
- W1567932233 hasConceptScore W1567932233C2776914184 @default.
- W1567932233 hasConceptScore W1567932233C2777397205 @default.
- W1567932233 hasConceptScore W1567932233C2777761686 @default.
- W1567932233 hasConceptScore W1567932233C2778488018 @default.
- W1567932233 hasConceptScore W1567932233C2778754761 @default.
- W1567932233 hasConceptScore W1567932233C2780159080 @default.
- W1567932233 hasConceptScore W1567932233C2780931953 @default.
- W1567932233 hasConceptScore W1567932233C71924100 @default.
- W1567932233 hasConceptScore W1567932233C8891405 @default.
- W1567932233 hasIssue "S1" @default.
- W1567932233 hasLocation W15679322331 @default.
- W1567932233 hasOpenAccess W1567932233 @default.
- W1567932233 hasPrimaryLocation W15679322331 @default.
- W1567932233 hasRelatedWork W1567932233 @default.
- W1567932233 hasRelatedWork W2042288045 @default.
- W1567932233 hasRelatedWork W2092387810 @default.
- W1567932233 hasRelatedWork W2151014874 @default.
- W1567932233 hasRelatedWork W2263307001 @default.
- W1567932233 hasRelatedWork W2364001027 @default.
- W1567932233 hasRelatedWork W2743669296 @default.
- W1567932233 hasRelatedWork W2763741496 @default.
- W1567932233 hasRelatedWork W2895286567 @default.
- W1567932233 hasRelatedWork W3090161233 @default.
- W1567932233 hasVolume "28" @default.
- W1567932233 isParatext "false" @default.
- W1567932233 isRetracted "false" @default.
- W1567932233 magId "1567932233" @default.
- W1567932233 workType "article" @default.