FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567941389> ?p ?o ?g. }

• W1567941389 endingPage "603" @default.
• W1567941389 startingPage "591" @default.
• W1567941389 abstract "Clinical and experimental studies have established eosinophilia as a sign of allergic disorders. Activation of eosinophils in the airways is believed to cause epithelial tissue injury, contraction of airway smooth muscle and increased bronchial responsiveness. As part of the search for new anti-asthmatic agents produced by medicinal plants, the effects of 270 standardized medicinal plant extracts on cytokine-activated A549 human lung epithelial cells were evaluated. After several rounds of activity-guided screening, the new natural compound, 1H,8H-Pyrano[3,4-c]pyran-1,8-dione (PPY), was isolated from Vitex rotundifolia L. To elucidate the mechanism by which the anti-asthmatic responses of PPY occurred in vitro, lung epithelial cells (A549 cell) were stimulated with TNF-α, IL-4 and IL-1β to induce the expression of chemokines and adhesion molecules involved in eosinophil chemotaxis. PPY treatments reduced the expression of eotaxin, IL-8, IL-16 and VCAM-1 mRNA significantly. Additionally, PPY reduced eotaxin secretion in a dose-dependent manner and significantly inhibited eosinophil migration toward A549 medium. In addition, PPY treatment suppressed the phosphorylation of p65 and ERK1/2, suggesting that it can inhibit the MAPK/NF-κβ pathway. To clarify the anti-inflammatory and anti-asthmatic effects of PPY in vivo, we examined the influence of PPY on the development of pulmonary eosinophilic inflammation in a murine model of asthma. To accomplish this, mice were sensitized and challenged with ovalbumin (OVA) and then examined for the following typical asthmatic reactions: an increase in the number of eosinophils in BALF; the presence of Th2 cytokines such as IL-4 and IL-5 in the BALF; the presence of allergen-specific IgE in the serum; and a marked influx of inflammatory cells into the lung. Taken together, our results revealed that PPY exerts profound inhibitory effects on the accumulation of eosinophils into the airways while reducing the levels of IL-4, IL-5, and IL-13 in the BALF. Therefore, these results suggest that PPY may be useful as a new therapeutic drug for the treatment of allergic asthma." @default.
• W1567941389 created "2016-06-24" @default.
• W1567941389 creator A5000268747 @default.
• W1567941389 creator A5001194169 @default.
• W1567941389 creator A5050283640 @default.
• W1567941389 creator A5052260212 @default.
• W1567941389 creator A5054439733 @default.
• W1567941389 creator A5054619950 @default.
• W1567941389 creator A5056256560 @default.
• W1567941389 creator A5084352457 @default.
• W1567941389 creator A5084668442 @default.
• W1567941389 date "2009-07-01" @default.
• W1567941389 modified "2023-10-01" @default.
• W1567941389 title "A New Compound, 1H,8H-Pyrano[3,4-C]Pyran-1,8-Dione, Suppresses Airway Epithelial Cell Inflammatory Responses in a Murine Model of Asthma" @default.
• W1567941389 cites W1554535093 @default.
• W1567941389 cites W1679925587 @default.
• W1567941389 cites W1879141735 @default.
• W1567941389 cites W1967777975 @default.
• W1567941389 cites W1988211480 @default.
• W1567941389 cites W1991540670 @default.
• W1567941389 cites W1995167724 @default.
• W1567941389 cites W2007599747 @default.
• W1567941389 cites W2009390007 @default.
• W1567941389 cites W2013132903 @default.
• W1567941389 cites W2021216394 @default.
• W1567941389 cites W2023520187 @default.
• W1567941389 cites W2027042060 @default.
• W1567941389 cites W2031880739 @default.
• W1567941389 cites W2033043906 @default.
• W1567941389 cites W2039533506 @default.
• W1567941389 cites W2040724802 @default.
• W1567941389 cites W2040783402 @default.
• W1567941389 cites W2052359947 @default.
• W1567941389 cites W2060763719 @default.
• W1567941389 cites W2062946709 @default.
• W1567941389 cites W2068616722 @default.
• W1567941389 cites W2071711382 @default.
• W1567941389 cites W2072246564 @default.
• W1567941389 cites W2074537289 @default.
• W1567941389 cites W2081940646 @default.
• W1567941389 cites W2082752613 @default.
• W1567941389 cites W2087251851 @default.
• W1567941389 cites W2088957112 @default.
• W1567941389 cites W2092120571 @default.
• W1567941389 cites W2095995468 @default.
• W1567941389 cites W2139857918 @default.
• W1567941389 cites W2143100241 @default.
• W1567941389 cites W2160220254 @default.
• W1567941389 cites W2164200480 @default.
• W1567941389 cites W4313309880 @default.
• W1567941389 doi "https://doi.org/10.1177/039463200902200305" @default.
• W1567941389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19822076" @default.
• W1567941389 hasPublicationYear "2009" @default.
• W1567941389 type Work @default.
• W1567941389 sameAs 1567941389 @default.
• W1567941389 citedByCount "18" @default.
• W1567941389 countsByYear W15679413892013 @default.
• W1567941389 countsByYear W15679413892014 @default.
• W1567941389 countsByYear W15679413892015 @default.
• W1567941389 countsByYear W15679413892017 @default.
• W1567941389 countsByYear W15679413892019 @default.
• W1567941389 countsByYear W15679413892020 @default.
• W1567941389 countsByYear W15679413892022 @default.
• W1567941389 countsByYear W15679413892023 @default.
• W1567941389 crossrefType "journal-article" @default.
• W1567941389 hasAuthorship W1567941389A5000268747 @default.
• W1567941389 hasAuthorship W1567941389A5001194169 @default.
• W1567941389 hasAuthorship W1567941389A5050283640 @default.
• W1567941389 hasAuthorship W1567941389A5052260212 @default.
• W1567941389 hasAuthorship W1567941389A5054439733 @default.
• W1567941389 hasAuthorship W1567941389A5054619950 @default.
• W1567941389 hasAuthorship W1567941389A5056256560 @default.
• W1567941389 hasAuthorship W1567941389A5084352457 @default.
• W1567941389 hasAuthorship W1567941389A5084668442 @default.
• W1567941389 hasBestOaLocation W15679413891 @default.
• W1567941389 hasConcept C13373296 @default.
• W1567941389 hasConcept C150903083 @default.
• W1567941389 hasConcept C185592680 @default.
• W1567941389 hasConcept C202751555 @default.
• W1567941389 hasConcept C203014093 @default.
• W1567941389 hasConcept C207001950 @default.
• W1567941389 hasConcept C2776042228 @default.
• W1567941389 hasConcept C2776914184 @default.
• W1567941389 hasConcept C2776946954 @default.
• W1567941389 hasConcept C2777037409 @default.
• W1567941389 hasConcept C2777716647 @default.
• W1567941389 hasConcept C2778690821 @default.
• W1567941389 hasConcept C2779675166 @default.
• W1567941389 hasConcept C55493867 @default.
• W1567941389 hasConcept C71924100 @default.
• W1567941389 hasConcept C81729549 @default.
• W1567941389 hasConcept C86803240 @default.
• W1567941389 hasConcept C8891405 @default.
• W1567941389 hasConcept C98274493 @default.
• W1567941389 hasConceptScore W1567941389C13373296 @default.
• W1567941389 hasConceptScore W1567941389C150903083 @default.
• W1567941389 hasConceptScore W1567941389C185592680 @default.
• W1567941389 hasConceptScore W1567941389C202751555 @default.

• next