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- W1567954137 abstract "Given the scarcity of effective therapeutic options for malignant melanoma, research efforts have focused on understanding mechanisms of melanoma initiation and progression in order to develop novel treatment strategies. Numerous studies now implicate changes in the activity of both β-catenin-dependent Wnt signaling pathways and β-catenin-independent Wnt signaling pathways in melanoma development and progression. This chapter attempts to answer the following critical questions regarding the Wnt signaling pathways in melanoma: (i) Can measures of Wnt signaling activity provide any prognostic information in a clinical setting? (ii) How do Wnt signaling pathways functionally contribute to melanoma tumorigenesis, progression, and/or metastasis? (iii) What endogenous and exogenous factors determine the relative activity of Wnt signaling pathways in melanoma? and (iv) Can we leverage our emerging understanding of Wnt signaling towards the development of new clinical strategies for therapeutically intractable melanomas?" @default.
- W1567954137 created "2016-06-24" @default.
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- W1567954137 date "2014-03-07" @default.
- W1567954137 modified "2023-10-18" @default.
- W1567954137 title "Wnt Signaling in Melanoma" @default.
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- W1567954137 doi "https://doi.org/10.1002/9781118444122.ch28" @default.
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