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- W1567964050 abstract "Publisher Summary This chapter discusses systemic stress-induced T helper-2 (Th2) shift and its clinical implications. Stress hormones selectively suppress T helper-1 (Th1) responses and cause a Th2 shift rather than generalized immunosuppression. The stress hormone–induced Th2 shift may have both beneficial and detrimental consequences. Although interest in the Th2 response is initially directed at its protective role in helminthic infections and its pathogenic role in allergy, this response may have important regulatory functions in countering the tissue-damaging effects of macrophages and Th1 cells. Thus, an excessive immune response, through activation of the stress system, may trigger a mechanism that inhibits Th1 but potentiates Th2 responses. This important feedback mechanism may protect the organism from overshooting by type 1/pro-inflammatory cytokines and other products of activated macrophages with tissue-damaging potential. The substantial Th2-driving force, however, of endogenous glucocorticoids and catecholamines (CAs) can be amplified to a great extent during certain conditions such as severe acute or chronic stress, excessive exercise, or pregnancy. An abnormal stress-system activity, therefore, in either direction, might contribute to the pathophysiology of common human diseases, where a selection of Th1 (type 1) versus Th2 (type 2) responses plays a significant role. These include several intracellular infections, major injury and its complications, allergic (atopic) reactions, autoimmune/inflammatory diseases, and tumor growth." @default.
- W1567964050 created "2016-06-24" @default.
- W1567964050 creator A5081545777 @default.
- W1567964050 date "2002-01-01" @default.
- W1567964050 modified "2023-10-12" @default.
- W1567964050 title "Systemic stress-induced Th2 shift and its clinical implications" @default.
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- W1567964050 doi "https://doi.org/10.1016/s0074-7742(02)52009-2" @default.
- W1567964050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12498104" @default.
- W1567964050 hasPublicationYear "2002" @default.
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