Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567984113> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1567984113 endingPage "169" @default.
- W1567984113 startingPage "160" @default.
- W1567984113 abstract "YM155 monobromide is a novel small-molecule survivin suppressant. The pharmacokinetics, distribution and excretion of YM155/[14C]YM155 were investigated using males and pregnant or lactating female rats after a single intravenous bolus administration. For the 0.1, 0.3 and 1 mg/kg YM155 doses given to male rats, increases in area under the plasma concentration-time curves were approximately proportional to the increase in the dose level. After administering [14C]YM155, radioactivity concentrations in the kidney and liver were highest among the tissues in both male and pregnant rats: e.g. 14.8- and 5.24-fold, respectively, and higher than in plasma at 0.1 h after dosing to male rats. The YM155 concentrations in the brain were lowest: 25-fold lower than in plasma. The transfer of radioactivity into fetuses was low (about 2-fold lower than in plasma). In lactating rats, the radioactivity was transferred into milk at a level 8- to 21-fold higher than for plasma. Radioactivity was primarily excreted in feces (64.0%) and urine (35.2%). The fecal excretion was considered to have occurred mainly by biliary excretion and partly by secretion across the gastrointestinal membrane from the blood to the lumen." @default.
- W1567984113 created "2016-06-24" @default.
- W1567984113 creator A5001003260 @default.
- W1567984113 creator A5005418119 @default.
- W1567984113 creator A5013182043 @default.
- W1567984113 creator A5027507560 @default.
- W1567984113 creator A5028454194 @default.
- W1567984113 creator A5030497460 @default.
- W1567984113 creator A5036118031 @default.
- W1567984113 creator A5055442183 @default.
- W1567984113 creator A5057461798 @default.
- W1567984113 date "2012-04-01" @default.
- W1567984113 modified "2023-09-26" @default.
- W1567984113 title "Pharmacokinetics, distribution and excretion of YM155 monobromide, a novel small-molecule survivin suppressant, in male and pregnant or lactating female rats" @default.
- W1567984113 cites W1500921061 @default.
- W1567984113 cites W152943885 @default.
- W1567984113 cites W1963786645 @default.
- W1567984113 cites W1979352058 @default.
- W1567984113 cites W1979853978 @default.
- W1567984113 cites W1981006523 @default.
- W1567984113 cites W2011927751 @default.
- W1567984113 cites W2025894603 @default.
- W1567984113 cites W2031068970 @default.
- W1567984113 cites W2033020367 @default.
- W1567984113 cites W2035090455 @default.
- W1567984113 cites W2035523654 @default.
- W1567984113 cites W2037249620 @default.
- W1567984113 cites W2045837215 @default.
- W1567984113 cites W2083331907 @default.
- W1567984113 cites W2087522889 @default.
- W1567984113 cites W2087681835 @default.
- W1567984113 cites W2111129058 @default.
- W1567984113 cites W2136763277 @default.
- W1567984113 cites W2139533680 @default.
- W1567984113 cites W2140677989 @default.
- W1567984113 cites W2172124462 @default.
- W1567984113 cites W27333370 @default.
- W1567984113 doi "https://doi.org/10.1002/bdd.1781" @default.
- W1567984113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22374735" @default.
- W1567984113 hasPublicationYear "2012" @default.
- W1567984113 type Work @default.
- W1567984113 sameAs 1567984113 @default.
- W1567984113 citedByCount "12" @default.
- W1567984113 countsByYear W15679841132014 @default.
- W1567984113 countsByYear W15679841132016 @default.
- W1567984113 countsByYear W15679841132017 @default.
- W1567984113 countsByYear W15679841132018 @default.
- W1567984113 countsByYear W15679841132019 @default.
- W1567984113 countsByYear W15679841132020 @default.
- W1567984113 countsByYear W15679841132023 @default.
- W1567984113 crossrefType "journal-article" @default.
- W1567984113 hasAuthorship W1567984113A5001003260 @default.
- W1567984113 hasAuthorship W1567984113A5005418119 @default.
- W1567984113 hasAuthorship W1567984113A5013182043 @default.
- W1567984113 hasAuthorship W1567984113A5027507560 @default.
- W1567984113 hasAuthorship W1567984113A5028454194 @default.
- W1567984113 hasAuthorship W1567984113A5030497460 @default.
- W1567984113 hasAuthorship W1567984113A5036118031 @default.
- W1567984113 hasAuthorship W1567984113A5055442183 @default.
- W1567984113 hasAuthorship W1567984113A5057461798 @default.
- W1567984113 hasConcept C10146269 @default.
- W1567984113 hasConcept C112705442 @default.
- W1567984113 hasConcept C126322002 @default.
- W1567984113 hasConcept C134018914 @default.
- W1567984113 hasConcept C185592680 @default.
- W1567984113 hasConcept C71924100 @default.
- W1567984113 hasConcept C86803240 @default.
- W1567984113 hasConceptScore W1567984113C10146269 @default.
- W1567984113 hasConceptScore W1567984113C112705442 @default.
- W1567984113 hasConceptScore W1567984113C126322002 @default.
- W1567984113 hasConceptScore W1567984113C134018914 @default.
- W1567984113 hasConceptScore W1567984113C185592680 @default.
- W1567984113 hasConceptScore W1567984113C71924100 @default.
- W1567984113 hasConceptScore W1567984113C86803240 @default.
- W1567984113 hasIssue "3" @default.
- W1567984113 hasLocation W15679841131 @default.
- W1567984113 hasLocation W15679841132 @default.
- W1567984113 hasOpenAccess W1567984113 @default.
- W1567984113 hasPrimaryLocation W15679841131 @default.
- W1567984113 hasRelatedWork W2005434179 @default.
- W1567984113 hasRelatedWork W2021846613 @default.
- W1567984113 hasRelatedWork W2022389305 @default.
- W1567984113 hasRelatedWork W2028993205 @default.
- W1567984113 hasRelatedWork W2074872267 @default.
- W1567984113 hasRelatedWork W2088386184 @default.
- W1567984113 hasRelatedWork W2093166709 @default.
- W1567984113 hasRelatedWork W2104218156 @default.
- W1567984113 hasRelatedWork W2112174287 @default.
- W1567984113 hasRelatedWork W84213784 @default.
- W1567984113 hasVolume "33" @default.
- W1567984113 isParatext "false" @default.
- W1567984113 isRetracted "false" @default.
- W1567984113 magId "1567984113" @default.
- W1567984113 workType "article" @default.