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- W1567991807 abstract "The effect of interferon-γ (IFN-γ) on lipopolysaccharide (LPS)-induced cytokine production has been examined in adult rat brain microglia. Following treatment of isolated cells in vitro with LPS, interleukin-1 (IL-1) and interleukin-6 (IL-6) levels in culture supernatants, determined by bioassay, were increased in a dose-dependent manner. IL-6 was particularly sensitive to LPS-stimulation. Using in situ hybridisation techniques, the induction by LPS of IL-1 and IL-6 mRNA in cultured microglia has been demonstrated. When IFN-γ was included, LPS-induced production of both IL-1 and IL-6 by microglia was significantly reduced and this effect was particularly marked in the case of IL-1. Comparisons with peritoneal macrophages demonstrate that whilst both cell types produce IL-1 and IL-6 in response to LPS, IFN-γ had no significant effect on this response in peritoneal macrophages. This suggests potential control mechanisms which may be effective in down-regulating cytokine production by microglia in vivo. Copyright © 1996 Elsevier Science Ltd." @default.
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- W1567991807 date "1996-07-01" @default.
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- W1567991807 title "INHIBITORY EFFECT OF INTERFERON-γ ON LPS-INDUCED INTERLEUKIN 1β PRODUCTION BY ISOLATED ADULT RAT BRAIN MICROGLIA**This is one of eight original papers on the subject “microglia”. Dr Peter Gebicke-Haerter (Dept. Psychiatry, University of Freiburg, Germany) acted as organiser and executive editor in the refereeing of these articles." @default.
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- W1567991807 doi "https://doi.org/10.1016/0197-0186(95)00135-2" @default.
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