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- W1568072017 abstract "Male weanling rats were fed a vitamin-free casein basal diet containing 0.5% succinylsulfathiazole plus 20% by weight of fats of varying degrees of unsaturation. Rats fed the biotin-deficient corn oil diet weighed significantly (P < 0.05) less than the control animals fed a diet supplemented with 2 mg biotin/kilogram diet and those fed the hydrogenated vegetable fat diet with or without added biotin. Addition of 3% sodium propionate depressed growth (P < 0.05) of the rats fed the biotin-deficient corn oil diet. In a second experiment, a significant (P < 0.01) growth depression was observed in biotin-deficient rats fed diets containing either corn oil or safflower oil as the fat source. The biotin-deficient rats excreted significantly (P < 0.05) greater amounts of urinary 14C-labeled propionate 24 to 48 hours after intraperitoneal injection of linoleate-U-14C than did the biotin-supplemented control rats. The accentuation of growth depression due to a biotin deficiency by unsaturated dietary fat and the increased excretion of 14C-labeled propionate from linoleate-U-14C by biotin-deficient rats support the hypothesis for the gamma-oxidation of linoleate." @default.
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- W1568072017 date "1972-06-01" @default.
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- W1568072017 title "Effect of Biotin Deficiency on the Catabolism of Linoleate in the Rat" @default.
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- W1568072017 doi "https://doi.org/10.1093/jn/102.6.767" @default.
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