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• W1568165046 abstract "Background: During retinal and spinal cord neurogenesis, Notch signaling plays crucial roles in regulating proliferation and differentiation of progenitor cells. One of the Notch ligands, Delta-like 4 (Dll4), has been shown to be expressed in subsets of retinal and spinal cord progenitors/precursors and involved in neuronal subtype specification. However, it remains to be determined whether Dll4 expression has any progenitor/precursor-specificity contributing to its functional specificity during neural development. Results: We generated a Dll4-Cre BAC transgenic mouse line that drives Cre recombinase expression mimicking that of the endogenous Dll4 in the developing retina and spinal cord. By fate-mapping analysis, we found that Dll4-expressing progenitors/precursors give rise to essentially all cone, amacrine and horizontal cells, a large portion of rod and ganglion cells, but only few bipolar and Müller cells. In the spinal cord, Dll4-expressing progenitors/precursors generate almost all V2a and V2c cells while producing only a fraction of the cells for other interneuron and motor neuron subtypes along the dorsoventral axis. Conclusions: Our data suggest that selective expression of Dll4 in progenitors/precursors contributes to its functional specificity in neuronal specification and that the Dll4-Cre line is a valuable tool for gene manipulation to study Notch signaling. Developmental Dynamics 244:86–97, 2015. © 2014 Wiley Periodicals, Inc." @default.
• W1568165046 created "2016-06-24" @default.
• W1568165046 creator A5054225091 @default.
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• W1568165046 date "2014-09-16" @default.
• W1568165046 modified "2023-10-16" @default.
• W1568165046 title "Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord" @default.
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• W1568165046 cites W1971626524 @default.
• W1568165046 cites W1971636570 @default.
• W1568165046 cites W1985657116 @default.
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• W1568165046 doi "https://doi.org/10.1002/dvdy.24185" @default.
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