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- W1568174629 endingPage "4931" @default.
- W1568174629 startingPage "4912" @default.
- W1568174629 abstract "Bone substitute materials have witnessed tremendous development over the past decades and autogenous bone may still be considered the gold standard for many clinicians and clinical approaches in order to rebuild and restore bone defects. However, a plethora of novel xenogenic and synthetic bone substitute materials have been introduced in recent years in the field of bone regeneration. As the development of bone is actually a calcification process within a collagen fiber arrangement, the use of scaffolds in the formation of fibers may offer some advantages, along with additional handling characteristics. This review focuses on material characteristics and degradation behavior of electrospun biodegradable polyester scaffolds. Furthermore, we concentrated on the preclinical in vivo performance with regard to bone regeneration in preclinical studies. The major findings are as follows: Scaffold composition and architecture determine its biological behavior and degradation characteristics; The incorporation of inorganic substances and/or organic substances within composite scaffolds enhances new bone formation; L-poly(lactic acid) and poly(lactic-co-glycolic acid) composite scaffolds, especially when combined with basic substances like hydroxyapatite, tricalcium phosphate or demineralized bone powder, seem not to induce inflammatory tissue reactions in vivo." @default.
- W1568174629 created "2016-06-24" @default.
- W1568174629 creator A5018738417 @default.
- W1568174629 creator A5022388582 @default.
- W1568174629 creator A5071974915 @default.
- W1568174629 creator A5085701003 @default.
- W1568174629 date "2015-08-03" @default.
- W1568174629 modified "2023-09-30" @default.
- W1568174629 title "Preclinical in vivo Performance of Novel Biodegradable, Electrospun Poly(lactic acid) and Poly(lactic-co-glycolic acid) Nanocomposites: A Review" @default.
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- W1568174629 doi "https://doi.org/10.3390/ma8084912" @default.
- W1568174629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5455478" @default.
- W1568174629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28793481" @default.
- W1568174629 hasPublicationYear "2015" @default.
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