FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1568338279> ?p ?o ?g. }

• W1568338279 endingPage "156" @default.
• W1568338279 startingPage "146" @default.
• W1568338279 abstract "Background: Congenital loss of the SHOX gene is considered to be a genetic cause of short stature phenotype in Turner syndrome and Leri-Weill dyschondrosteosis patients. Though SHOX expression initiates during early fetal development, little is known about the embryonic roles of SHOX. The evolutionary conservation of the zebrafish shox gene and the convenience of the early developmental stages for analyses make zebrafish a preferred model. Here, we characterized structure, expression, and developmental roles of zebrafish shox through a loss-of-function approach. Results: We found a previously undiscovered Shox protein that has both a homeodomain and an OAR-domain in zebrafish. The shox transcript emerged during the segmentation period and it increased in later stages. The predominant domains of shox expression were mandibular arch, pectoral fin, anterior notochord, rhombencephalon, and mesencephalon, suggesting that Shox is involved in bone and neural development. Translational blockade of Shox mRNA by an antisense morpholino oligo delayed embryonic growth, which was restored by the co-overexpression of morpholino-resistant Shox mRNA. At later stages, impaired Shox expression markedly delayed the calcification process in the anterior vertebral column and craniofacial bones. Conclusions: Our data demonstrate evolutionarily conserved Shox plays roles in early embryonic growth and in later bone formation. Developmental Dynamics 244:146–156, 2015. © 2014 Wiley Periodicals, Inc." @default.
• W1568338279 created "2016-06-24" @default.
• W1568338279 creator A5001206797 @default.
• W1568338279 creator A5014201910 @default.
• W1568338279 creator A5037983120 @default.
• W1568338279 creator A5042621717 @default.
• W1568338279 creator A5075622357 @default.
• W1568338279 date "2014-12-30" @default.
• W1568338279 modified "2023-09-30" @default.
• W1568338279 title "In vivo loss of function study reveals the<i>short stature homeobox-containing</i>(<i>shox</i>) gene plays indispensable roles in early embryonic growth and bone formation in zebrafish" @default.
• W1568338279 cites W1527940466 @default.
• W1568338279 cites W1972259766 @default.
• W1568338279 cites W1975874715 @default.
• W1568338279 cites W1976781053 @default.
• W1568338279 cites W1979043688 @default.
• W1568338279 cites W1979173183 @default.
• W1568338279 cites W1985618120 @default.
• W1568338279 cites W1994536036 @default.
• W1568338279 cites W2000260132 @default.
• W1568338279 cites W2000375473 @default.
• W1568338279 cites W2004876851 @default.
• W1568338279 cites W2005759400 @default.
• W1568338279 cites W2009445610 @default.
• W1568338279 cites W2012670311 @default.
• W1568338279 cites W2018425216 @default.
• W1568338279 cites W2063298301 @default.
• W1568338279 cites W2066556421 @default.
• W1568338279 cites W2071852892 @default.
• W1568338279 cites W2088357803 @default.
• W1568338279 cites W2091222913 @default.
• W1568338279 cites W2093494317 @default.
• W1568338279 cites W2093901076 @default.
• W1568338279 cites W2096807605 @default.
• W1568338279 cites W2097421667 @default.
• W1568338279 cites W2102043876 @default.
• W1568338279 cites W2104784626 @default.
• W1568338279 cites W2108671049 @default.
• W1568338279 cites W2110500383 @default.
• W1568338279 cites W2116511113 @default.
• W1568338279 cites W2117442933 @default.
• W1568338279 cites W2122913700 @default.
• W1568338279 cites W2124329191 @default.
• W1568338279 cites W2125349610 @default.
• W1568338279 cites W2129697023 @default.
• W1568338279 cites W2134626110 @default.
• W1568338279 cites W2138431386 @default.
• W1568338279 cites W2141413750 @default.
• W1568338279 cites W2145891111 @default.
• W1568338279 cites W2147261093 @default.
• W1568338279 cites W2155246478 @default.
• W1568338279 cites W2157381937 @default.
• W1568338279 cites W2168177780 @default.
• W1568338279 cites W2223426554 @default.
• W1568338279 cites W2340730686 @default.
• W1568338279 doi "https://doi.org/10.1002/dvdy.24239" @default.
• W1568338279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25483930" @default.
• W1568338279 hasPublicationYear "2014" @default.
• W1568338279 type Work @default.
• W1568338279 sameAs 1568338279 @default.
• W1568338279 citedByCount "17" @default.
• W1568338279 countsByYear W15683382792015 @default.
• W1568338279 countsByYear W15683382792016 @default.
• W1568338279 countsByYear W15683382792017 @default.
• W1568338279 countsByYear W15683382792018 @default.
• W1568338279 countsByYear W15683382792019 @default.
• W1568338279 countsByYear W15683382792020 @default.
• W1568338279 countsByYear W15683382792021 @default.
• W1568338279 countsByYear W15683382792022 @default.
• W1568338279 countsByYear W15683382792023 @default.
• W1568338279 crossrefType "journal-article" @default.
• W1568338279 hasAuthorship W1568338279A5001206797 @default.
• W1568338279 hasAuthorship W1568338279A5014201910 @default.
• W1568338279 hasAuthorship W1568338279A5037983120 @default.
• W1568338279 hasAuthorship W1568338279A5042621717 @default.
• W1568338279 hasAuthorship W1568338279A5075622357 @default.
• W1568338279 hasBestOaLocation W15683382791 @default.
• W1568338279 hasConcept C104317684 @default.
• W1568338279 hasConcept C105702510 @default.
• W1568338279 hasConcept C121587040 @default.
• W1568338279 hasConcept C126322002 @default.
• W1568338279 hasConcept C134018914 @default.
• W1568338279 hasConcept C136571751 @default.
• W1568338279 hasConcept C150194340 @default.
• W1568338279 hasConcept C2776878037 @default.
• W1568338279 hasConcept C54355233 @default.
• W1568338279 hasConcept C71924100 @default.
• W1568338279 hasConcept C86803240 @default.
• W1568338279 hasConceptScore W1568338279C104317684 @default.
• W1568338279 hasConceptScore W1568338279C105702510 @default.
• W1568338279 hasConceptScore W1568338279C121587040 @default.
• W1568338279 hasConceptScore W1568338279C126322002 @default.
• W1568338279 hasConceptScore W1568338279C134018914 @default.
• W1568338279 hasConceptScore W1568338279C136571751 @default.
• W1568338279 hasConceptScore W1568338279C150194340 @default.
• W1568338279 hasConceptScore W1568338279C2776878037 @default.
• W1568338279 hasConceptScore W1568338279C54355233 @default.
• W1568338279 hasConceptScore W1568338279C71924100 @default.
• W1568338279 hasConceptScore W1568338279C86803240 @default.

• next