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- W1568366799 abstract "Publisher Summary This chapter discusses the role of caspases and cytokines in inflammation and autoimmunity. Caspases are a family of intracellular cysteine proteases that cleave their specific substrates at aspartic acid residues. Caspases are absolutely required for the production of several proinflammatory cytokines, including IL-lα, IL-lβ, IL-18, and probably interferon-γ. These cysteine proteases also play a requisite role in the signaling mechanisms by which several tumor necrosis factor (TNF) family receptors—including those for TNFα, FasL, Apo-3L, and TRAIL—induce cellular apoptosis and tissue destruction. These proteases have been implicated in two aspects of cytokine biology: (1) proteolytic processing and bioactivation of the proforms of certain interleukins (ILs), such as pro-IL-lβ and pro-IL-18, and (2) signaling by apoptosis-inducing members of the TNF receptor family, such as tumor necrosis factor receptor-1 (TNFR-1) (CD120a) and Fas (CD95). Moreover, these caspases appear to play nonredundant roles in a wide variety of cytokine-mediated inflammatory and autoimmune diseases. The involvement of caspases in cytokine biology is examined in the chapter, with special emphasis on its relevance to infectious diseases, inflammation, and autoimmunity. From this analysis, clinical indications for caspase-inhibiting drugs can be deduced and appropriate clinical trials can be initiated to test their efficacy in humans." @default.
- W1568366799 created "2016-06-24" @default.
- W1568366799 creator A5059438505 @default.
- W1568366799 date "1999-01-01" @default.
- W1568366799 modified "2023-09-25" @default.
- W1568366799 title "Caspases and Cytokines: Roles in Inflammation and Autoimmunity" @default.
- W1568366799 cites W1010417915 @default.
- W1568366799 cites W127313292 @default.
- W1568366799 cites W1492606093 @default.
- W1568366799 cites W1497298414 @default.
- W1568366799 cites W1497402347 @default.
- W1568366799 cites W1514081838 @default.
- W1568366799 cites W1514099677 @default.
- W1568366799 cites W1526571057 @default.
- W1568366799 cites W1566676785 @default.
- W1568366799 cites W1615239198 @default.
- W1568366799 cites W1616910822 @default.
- W1568366799 cites W1829961297 @default.
- W1568366799 cites W1840817809 @default.
- W1568366799 cites W1888783223 @default.
- W1568366799 cites W1964977785 @default.
- W1568366799 cites W1965233413 @default.
- W1568366799 cites W1966700067 @default.
- W1568366799 cites W1968328677 @default.
- W1568366799 cites W1969158591 @default.
- W1568366799 cites W1969771851 @default.
- W1568366799 cites W1970770376 @default.
- W1568366799 cites W1971449558 @default.
- W1568366799 cites W1972185183 @default.
- W1568366799 cites W1974393084 @default.
- W1568366799 cites W1974603163 @default.
- W1568366799 cites W1975870295 @default.
- W1568366799 cites W1976467696 @default.
- W1568366799 cites W1978417778 @default.
- W1568366799 cites W1979444649 @default.
- W1568366799 cites W1979842763 @default.
- W1568366799 cites W1979998867 @default.
- W1568366799 cites W1982836364 @default.
- W1568366799 cites W1985520226 @default.
- W1568366799 cites W1986228861 @default.
- W1568366799 cites W1986308149 @default.
- W1568366799 cites W1987931310 @default.
- W1568366799 cites W1989134194 @default.
- W1568366799 cites W1991170866 @default.
- W1568366799 cites W1993864683 @default.
- W1568366799 cites W1995871393 @default.
- W1568366799 cites W1998253405 @default.
- W1568366799 cites W1998585620 @default.
- W1568366799 cites W1999425834 @default.
- W1568366799 cites W2004645606 @default.
- W1568366799 cites W2008261126 @default.
- W1568366799 cites W2008794819 @default.
- W1568366799 cites W2013545866 @default.
- W1568366799 cites W2015872830 @default.
- W1568366799 cites W2017578232 @default.
- W1568366799 cites W2017728303 @default.
- W1568366799 cites W2017985723 @default.
- W1568366799 cites W2022015605 @default.
- W1568366799 cites W2023396428 @default.
- W1568366799 cites W2025559703 @default.
- W1568366799 cites W2027456984 @default.
- W1568366799 cites W2028111124 @default.
- W1568366799 cites W2028286862 @default.
- W1568366799 cites W2029599607 @default.
- W1568366799 cites W2030892254 @default.
- W1568366799 cites W2031283014 @default.
- W1568366799 cites W2032417513 @default.
- W1568366799 cites W2033228977 @default.
- W1568366799 cites W2034325959 @default.
- W1568366799 cites W2036528355 @default.
- W1568366799 cites W2037804577 @default.
- W1568366799 cites W2038212272 @default.
- W1568366799 cites W2038432548 @default.
- W1568366799 cites W2040810776 @default.
- W1568366799 cites W2040852036 @default.
- W1568366799 cites W2042812858 @default.
- W1568366799 cites W2052895824 @default.
- W1568366799 cites W2055061093 @default.
- W1568366799 cites W2055752453 @default.
- W1568366799 cites W2056469110 @default.
- W1568366799 cites W2057979643 @default.
- W1568366799 cites W2058384478 @default.
- W1568366799 cites W2059351462 @default.
- W1568366799 cites W2060294541 @default.
- W1568366799 cites W2060724258 @default.
- W1568366799 cites W2061359959 @default.
- W1568366799 cites W2061786750 @default.
- W1568366799 cites W2062354024 @default.
- W1568366799 cites W2063053561 @default.
- W1568366799 cites W2065257477 @default.
- W1568366799 cites W2065413461 @default.
- W1568366799 cites W2066096456 @default.
- W1568366799 cites W2067534266 @default.
- W1568366799 cites W2069242926 @default.
- W1568366799 cites W2071343795 @default.
- W1568366799 cites W2074192294 @default.
- W1568366799 cites W2075801864 @default.
- W1568366799 cites W2076719655 @default.