FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1568373087> ?p ?o ?g. }

• W1568373087 endingPage "e391" @default.
• W1568373087 startingPage "e381" @default.
• W1568373087 abstract "Background One of the hallmarks of acute colitis is loss of epithelial transport. For unknown reasons, many patients still suffer from GI symptoms during remission, indicating a sustained imbalance between absorption and secretion. We hypothesize that the colonic epithelium becomes more reactive to secretagogues to compensate for a failing barrier. Methods Biopsies from ascending colon and sigmoid colon of UC patients in remission and controls were mounted in Ussing chambers. Membrane current (Im) and epithelial capacitance (Cp) were used as markers for anion secretion and mucus exocytosis. Carbachol (1 mmol L−1) and forskolin (10 μmol L−1) were used to study Ca2+ and cAMP-mediated secretion. Key Results Baseline values showed segmental patterns with higher Im in ascending colon and higher Cp in sigmoid colon of both UC patients and controls, but the patterns did not differ between the groups. The Im response to forskolin was increased (+35%) in the ascending colon of UC patients and the Im response to carbachol was decreased (−40%) in the same segment. No group differences were seen in the distal colon for either the forskolin or carbachol-induced Im responses. The Cp response to carbachol was instead up-regulated in the distal colon of UC patients, but remained unaffected in the proximal colon. Conclusions & Inferences The proximal colonic mucosa of UC patients in remission seems to shift its reactivity to secretagogues, becoming more sensitive to cAMP-dependent secretion and less sensitive to Ca2+-dependent secretion. This phenomenon may contribute to residual diarrhea in this patient group, despite resolution of inflammation." @default.
• W1568373087 created "2016-06-24" @default.
• W1568373087 creator A5007674070 @default.
• W1568373087 creator A5009889118 @default.
• W1568373087 creator A5036876226 @default.
• W1568373087 date "2012-06-24" @default.
• W1568373087 modified "2023-10-14" @default.
• W1568373087 title "Ulcerative colitis patients in remission have an altered secretory capacity in the proximal colon despite macroscopically normal mucosa" @default.
• W1568373087 cites W1503660683 @default.
• W1568373087 cites W1505299894 @default.
• W1568373087 cites W1505729347 @default.
• W1568373087 cites W1508503273 @default.
• W1568373087 cites W1667676744 @default.
• W1568373087 cites W1968455380 @default.
• W1568373087 cites W1970224242 @default.
• W1568373087 cites W1970464559 @default.
• W1568373087 cites W1977188111 @default.
• W1568373087 cites W1982972448 @default.
• W1568373087 cites W2016417321 @default.
• W1568373087 cites W2018620221 @default.
• W1568373087 cites W2030364983 @default.
• W1568373087 cites W2031193040 @default.
• W1568373087 cites W2053875062 @default.
• W1568373087 cites W2058305185 @default.
• W1568373087 cites W2065797656 @default.
• W1568373087 cites W2085192123 @default.
• W1568373087 cites W2089752133 @default.
• W1568373087 cites W2121158588 @default.
• W1568373087 cites W2122530389 @default.
• W1568373087 cites W2128991181 @default.
• W1568373087 cites W2141060099 @default.
• W1568373087 cites W2141626158 @default.
• W1568373087 cites W2142781849 @default.
• W1568373087 cites W2152085581 @default.
• W1568373087 cites W2153075441 @default.
• W1568373087 cites W2153123240 @default.
• W1568373087 cites W2160942950 @default.
• W1568373087 cites W2167363404 @default.
• W1568373087 cites W2188484637 @default.
• W1568373087 cites W2273127291 @default.
• W1568373087 doi "https://doi.org/10.1111/j.1365-2982.2012.01958.x" @default.
• W1568373087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4871264" @default.
• W1568373087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22726848" @default.
• W1568373087 hasPublicationYear "2012" @default.
• W1568373087 type Work @default.
• W1568373087 sameAs 1568373087 @default.
• W1568373087 citedByCount "10" @default.
• W1568373087 countsByYear W15683730872013 @default.
• W1568373087 countsByYear W15683730872014 @default.
• W1568373087 countsByYear W15683730872016 @default.
• W1568373087 countsByYear W15683730872020 @default.
• W1568373087 countsByYear W15683730872022 @default.
• W1568373087 crossrefType "journal-article" @default.
• W1568373087 hasAuthorship W1568373087A5007674070 @default.
• W1568373087 hasAuthorship W1568373087A5009889118 @default.
• W1568373087 hasAuthorship W1568373087A5036876226 @default.
• W1568373087 hasBestOaLocation W15683730872 @default.
• W1568373087 hasConcept C126322002 @default.
• W1568373087 hasConcept C134018914 @default.
• W1568373087 hasConcept C170493617 @default.
• W1568373087 hasConcept C18903297 @default.
• W1568373087 hasConcept C2776870353 @default.
• W1568373087 hasConcept C2777312293 @default.
• W1568373087 hasConcept C2778988552 @default.
• W1568373087 hasConcept C2779134260 @default.
• W1568373087 hasConcept C2779276759 @default.
• W1568373087 hasConcept C2779932011 @default.
• W1568373087 hasConcept C2780479503 @default.
• W1568373087 hasConcept C2780833581 @default.
• W1568373087 hasConcept C2781074409 @default.
• W1568373087 hasConcept C3019368612 @default.
• W1568373087 hasConcept C49039625 @default.
• W1568373087 hasConcept C71924100 @default.
• W1568373087 hasConcept C86803240 @default.
• W1568373087 hasConcept C90924648 @default.
• W1568373087 hasConceptScore W1568373087C126322002 @default.
• W1568373087 hasConceptScore W1568373087C134018914 @default.
• W1568373087 hasConceptScore W1568373087C170493617 @default.
• W1568373087 hasConceptScore W1568373087C18903297 @default.
• W1568373087 hasConceptScore W1568373087C2776870353 @default.
• W1568373087 hasConceptScore W1568373087C2777312293 @default.
• W1568373087 hasConceptScore W1568373087C2778988552 @default.
• W1568373087 hasConceptScore W1568373087C2779134260 @default.
• W1568373087 hasConceptScore W1568373087C2779276759 @default.
• W1568373087 hasConceptScore W1568373087C2779932011 @default.
• W1568373087 hasConceptScore W1568373087C2780479503 @default.
• W1568373087 hasConceptScore W1568373087C2780833581 @default.
• W1568373087 hasConceptScore W1568373087C2781074409 @default.
• W1568373087 hasConceptScore W1568373087C3019368612 @default.
• W1568373087 hasConceptScore W1568373087C49039625 @default.
• W1568373087 hasConceptScore W1568373087C71924100 @default.
• W1568373087 hasConceptScore W1568373087C86803240 @default.
• W1568373087 hasConceptScore W1568373087C90924648 @default.
• W1568373087 hasIssue "8" @default.
• W1568373087 hasLocation W15683730871 @default.
• W1568373087 hasLocation W15683730872 @default.
• W1568373087 hasLocation W15683730873 @default.
• W1568373087 hasLocation W15683730874 @default.

• next