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- W1568519707 abstract "Publisher Summary This chapter describes corticobasal degeneration (CBD) as a complex neurodegenerative disorder with prominent tau-positive pathology in neurons and glia. CBD is often associated with a distinctive constellation of clinical findings known as the corticobasal syndrome (CBS); however it can also present as dementia and/or progressive aphasia. The chapter emphasizes that the current management of CBD–the disease and CBS–the syndrome is challenging. The chapter also reviews pharmacologic and rehabilitative strategies for addressing the motor, cognitive, and neuropsychiatric manifestations of the CBS. The chapter presents concepts and data that may prove important as clinical drug trials are designed using agents that affect tau pathophysiology in CBS/CBD. The primary goal in medicine is to prevent disease, and without a clear understanding of exactly what triggers the cascade of events that lead to neurodegeneration, a preventive approach to CBS/CBD will require much more work. A more realistic goal in the near future is therefore to slow the rate of progression once the earliest signs and symptoms have become evident. The chapter concludes that investigators should begin addressing the many challenges that lie ahead so that the foundation for drug trial development will be established and treatment trials can proceed quickly once tau-active drugs are identified." @default.
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- W1568519707 date "2008-01-01" @default.
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- W1568519707 title "Current and future management of the corticobasal syndrome and corticobasal degeneration" @default.
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- W1568519707 doi "https://doi.org/10.1016/s0072-9752(07)01249-3" @default.
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