Matches in SemOpenAlex for { <https://semopenalex.org/work/W1568574098> ?p ?o ?g. }
- W1568574098 endingPage "5669" @default.
- W1568574098 startingPage "5663" @default.
- W1568574098 abstract "Article history Alzheimer's disease (AD) is one of the most prevalent age related neurodegenerative disorders. AD is associated with the accumulation in the brain of extracellular neuritic plaques composed mainly of β-amyloid (Aβ) and of intracellular neurofibrillary tangles composed of hyperphosphorylated forms of the microtubule-associated protein tau. It is also associated with other features that have received less attention, including aberrant phospholipid, cholesterol, and calcium metabolism, and altered function and dynamics. Presenilin-1 (PS1), presenilin-2 (PS2), and γ-secretase activity, which processes the amyloid precursor protein (APP) to generate Aβ, are located predominantly in a specialized sub compartment of the endoplasmic reticulum (ER) that is physically and biochemically connected to mitochondria, called mitochondria-associated ER membranes (MAM). AD is fundamentally a disorder of ER-mitochondrial communication (the MAM hypothesis). Mitochondria-associated endoplasmic reticulum (ER) membranes (MAM), which are involved in the regulation of Ca 2+ signaling, phospholipids synthesis and apoptosis, are affected in AD. To date, the beta amyloid (Aβ) cascade still remains the main pathogenetic model of Alzheimer's disease (AD), but its role in the majority of sporadic AD cases is uncertain. Furthermore, the mitochondrial cascade hypothesis especially in relation to MAMS could explain many of the biochemical, genetic, and pathological features of sporadic AD." @default.
- W1568574098 created "2016-06-24" @default.
- W1568574098 creator A5007814260 @default.
- W1568574098 creator A5009181484 @default.
- W1568574098 creator A5044038247 @default.
- W1568574098 creator A5057318807 @default.
- W1568574098 creator A5074325232 @default.
- W1568574098 creator A5090349346 @default.
- W1568574098 date "2014-01-01" @default.
- W1568574098 modified "2023-09-24" @default.
- W1568574098 title "MITOCHONDRIA-ASSOCIATED MEMBRANES ('MAM') IN ALZHEIMER'S DISEASE" @default.
- W1568574098 cites W1493900409 @default.
- W1568574098 cites W1525966131 @default.
- W1568574098 cites W1564336783 @default.
- W1568574098 cites W1892274889 @default.
- W1568574098 cites W1940759671 @default.
- W1568574098 cites W1960363048 @default.
- W1568574098 cites W1967464308 @default.
- W1568574098 cites W1988664434 @default.
- W1568574098 cites W1989167108 @default.
- W1568574098 cites W1993463043 @default.
- W1568574098 cites W1998510870 @default.
- W1568574098 cites W2000742321 @default.
- W1568574098 cites W2010484888 @default.
- W1568574098 cites W2011705068 @default.
- W1568574098 cites W2014777707 @default.
- W1568574098 cites W2015097735 @default.
- W1568574098 cites W2019494456 @default.
- W1568574098 cites W2029553530 @default.
- W1568574098 cites W2037075564 @default.
- W1568574098 cites W2039069312 @default.
- W1568574098 cites W2045106215 @default.
- W1568574098 cites W2047217255 @default.
- W1568574098 cites W2050794707 @default.
- W1568574098 cites W2055383351 @default.
- W1568574098 cites W2055776806 @default.
- W1568574098 cites W2059005775 @default.
- W1568574098 cites W2061527930 @default.
- W1568574098 cites W2062628622 @default.
- W1568574098 cites W2080375658 @default.
- W1568574098 cites W2089982008 @default.
- W1568574098 cites W2092936855 @default.
- W1568574098 cites W2094347297 @default.
- W1568574098 cites W2096321546 @default.
- W1568574098 cites W2098329073 @default.
- W1568574098 cites W2098548022 @default.
- W1568574098 cites W2103024032 @default.
- W1568574098 cites W2105442740 @default.
- W1568574098 cites W2110171555 @default.
- W1568574098 cites W2117696416 @default.
- W1568574098 cites W2119808485 @default.
- W1568574098 cites W2120701804 @default.
- W1568574098 cites W2122245970 @default.
- W1568574098 cites W2136673626 @default.
- W1568574098 cites W213704492 @default.
- W1568574098 cites W2140014506 @default.
- W1568574098 cites W2149108521 @default.
- W1568574098 cites W2155643523 @default.
- W1568574098 cites W2162633290 @default.
- W1568574098 cites W2166131107 @default.
- W1568574098 cites W2172204522 @default.
- W1568574098 cites W2394563706 @default.
- W1568574098 cites W2399846959 @default.
- W1568574098 cites W35170014 @default.
- W1568574098 hasPublicationYear "2014" @default.
- W1568574098 type Work @default.
- W1568574098 sameAs 1568574098 @default.
- W1568574098 citedByCount "0" @default.
- W1568574098 crossrefType "journal-article" @default.
- W1568574098 hasAuthorship W1568574098A5007814260 @default.
- W1568574098 hasAuthorship W1568574098A5009181484 @default.
- W1568574098 hasAuthorship W1568574098A5044038247 @default.
- W1568574098 hasAuthorship W1568574098A5057318807 @default.
- W1568574098 hasAuthorship W1568574098A5074325232 @default.
- W1568574098 hasAuthorship W1568574098A5090349346 @default.
- W1568574098 hasConcept C142724271 @default.
- W1568574098 hasConcept C158617107 @default.
- W1568574098 hasConcept C175344181 @default.
- W1568574098 hasConcept C185592680 @default.
- W1568574098 hasConcept C2779134260 @default.
- W1568574098 hasConcept C28406088 @default.
- W1568574098 hasConcept C28859421 @default.
- W1568574098 hasConcept C31705614 @default.
- W1568574098 hasConcept C502032728 @default.
- W1568574098 hasConcept C55493867 @default.
- W1568574098 hasConcept C68026918 @default.
- W1568574098 hasConcept C71924100 @default.
- W1568574098 hasConcept C79879829 @default.
- W1568574098 hasConcept C86803240 @default.
- W1568574098 hasConcept C95444343 @default.
- W1568574098 hasConceptScore W1568574098C142724271 @default.
- W1568574098 hasConceptScore W1568574098C158617107 @default.
- W1568574098 hasConceptScore W1568574098C175344181 @default.
- W1568574098 hasConceptScore W1568574098C185592680 @default.
- W1568574098 hasConceptScore W1568574098C2779134260 @default.
- W1568574098 hasConceptScore W1568574098C28406088 @default.
- W1568574098 hasConceptScore W1568574098C28859421 @default.
- W1568574098 hasConceptScore W1568574098C31705614 @default.