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- W1568710114 abstract "Abstract CD28, a cell surface molecule expressed on all murine T cells, plays a critical role in T cell activation. We show here that NK-1.1+ cells, a subpopulation of SCID splenocytes, and IL-2-activated NK cells express CD28, although at lower levels than alpha beta T cells. Optimal proliferation of highly purified asialo GM1+ NK cells from the SCID spleen was observed in response to stimulation with IL-2 and PMA, together with anti-CD28 or L-B7+ cells. Thus, in addition to IL-2, murine NK cells require CD28-mediated costimulatory signals for optimal proliferation. IL-2-activated NK cells produced enhanced levels of IFN-gamma and TNF in response to stimulation with anti-CD28 and PMA. On the other hand, we were unable to demonstrate that CD28 signaling had any effect on NK-mediated cytotoxicity. We conclude that the CD28 costimulatory pathway is functional in NK cells and plays an important role in their proliferation and cytokine production." @default.
- W1568710114 created "2016-06-24" @default.
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- W1568710114 date "1994-04-01" @default.
- W1568710114 modified "2023-10-16" @default.
- W1568710114 title "CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells." @default.
- W1568710114 doi "https://doi.org/10.4049/jimmunol.152.7.3361" @default.
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