FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1568766475> ?p ?o ?g. }

• W1568766475 endingPage "4705" @default.
• W1568766475 startingPage "4691" @default.
• W1568766475 abstract "The hyperpolarization-activated current (I(h)) has been implicated in nociception/pain, but its expression levels in nociceptors remained unknown. We recorded I(h) magnitude and properties by voltage clamp from dorsal root ganglion (DRG) neurons in vivo, after classifying them as nociceptive or low-threshold-mechanoreceptors (LTMs) and as having C-, Aδ- or Aα/β-conduction velocities (CVs). For both nociceptors andLTMs, I(h) amplitude and I(h) density (at -100 mV) were significantly positively correlated with CV.Median I(h) magnitudes and I(h) density in neuronal subgroupswere respectively:muscle spindle afferents(MSAs):-4.6 nA,-33 pA pF(-1); cutaneous Aα/β LTMs: -2.2 nA, -20 pA pF(-1); Aβ-nociceptors: -2.6 nA, -21 pA pF(-1); both Aδ-LTMs and nociceptors: -1.3 nA, ∼-14 pA pF(-1); C-LTMs: -0.4 nA, -7.6 pA pF(-1); and C-nociceptors: -0.26 nA, -5 pApF(-1). I(h) activation slow time constants (slow τ values) were strongly correlated with fast τ values; both were shortest in MSAs. Most neurons had τ values consistent with HCN1-related I(h); others had τ values closer to HCN1+HCN2 channels, or HCN2 in the presence of cAMP. In contrast, median half-activation voltages (V(0.5)) of -80 to -86 mV for neuronal subgroups suggest contributions of HCN2 to I(h). τ values were unrelated to CV but were inversely correlated with I(h) and I(h) density for all non-MSA LTMs, and for Aδ-nociceptors. From activation curves ∼2-7% of I(h)would be activated at normal membrane potentials. The high I(h) may be important for excitability of A-nociceptors (responsible for sharp/pricking-type pain) and Aα/β-LTMs (tactile sensations and proprioception). Underlying HCN expression in these subgroups therefore needs to be determined. Altered high I(h) may be important for excitability of A-nociceptors (responsible for sharp/pricking-type pain) and Aα/β-LTMs (tactile sensations and proprioception). Underlying HCN expression in these subgroups therefore needs to be determined. Altered Ih expression and/or properties (e.g. in chronic/pathological pain states) may influence both nociceptor and LTM excitability.expression and/or properties (e.g. in chronic/pathological pain states) may influence both nociceptor and LTM excitability." @default.
• W1568766475 created "2016-06-24" @default.
• W1568766475 creator A5024731647 @default.
• W1568766475 creator A5047239811 @default.
• W1568766475 creator A5047580780 @default.
• W1568766475 creator A5055505451 @default.
• W1568766475 creator A5059992473 @default.
• W1568766475 creator A5077060771 @default.
• W1568766475 date "2012-08-06" @default.
• W1568766475 modified "2023-10-08" @default.
• W1568766475 title "Expression and properties of hyperpolarization‐activated current in rat dorsal root ganglion neurons with known sensory function" @default.
• W1568766475 cites W1831695691 @default.
• W1568766475 cites W1925234459 @default.
• W1568766475 cites W1966936758 @default.
• W1568766475 cites W1967619361 @default.
• W1568766475 cites W1976965902 @default.
• W1568766475 cites W1984829646 @default.
• W1568766475 cites W2001165107 @default.
• W1568766475 cites W2003066952 @default.
• W1568766475 cites W2003082472 @default.
• W1568766475 cites W2008142951 @default.
• W1568766475 cites W2008465842 @default.
• W1568766475 cites W2010728623 @default.
• W1568766475 cites W2016334402 @default.
• W1568766475 cites W2021166126 @default.
• W1568766475 cites W2023001234 @default.
• W1568766475 cites W2026769266 @default.
• W1568766475 cites W2026823182 @default.
• W1568766475 cites W2039517962 @default.
• W1568766475 cites W2042847772 @default.
• W1568766475 cites W2048805953 @default.
• W1568766475 cites W2049821160 @default.
• W1568766475 cites W2050888848 @default.
• W1568766475 cites W2060641239 @default.
• W1568766475 cites W2060972591 @default.
• W1568766475 cites W2066013539 @default.
• W1568766475 cites W2066942245 @default.
• W1568766475 cites W2069387230 @default.
• W1568766475 cites W2069421580 @default.
• W1568766475 cites W2084471888 @default.
• W1568766475 cites W2085813758 @default.
• W1568766475 cites W2087823674 @default.
• W1568766475 cites W2088689487 @default.
• W1568766475 cites W2107040951 @default.
• W1568766475 cites W2118621245 @default.
• W1568766475 cites W2123038571 @default.
• W1568766475 cites W2127329402 @default.
• W1568766475 cites W2128490398 @default.
• W1568766475 cites W2135531905 @default.
• W1568766475 cites W2140845062 @default.
• W1568766475 cites W2144299211 @default.
• W1568766475 cites W2155419660 @default.
• W1568766475 cites W2156881907 @default.
• W1568766475 cites W2161201932 @default.
• W1568766475 cites W2339693364 @default.
• W1568766475 cites W2399088380 @default.
• W1568766475 cites W2411384047 @default.
• W1568766475 cites W2443293063 @default.
• W1568766475 cites W2472213757 @default.
• W1568766475 cites W59136502 @default.
• W1568766475 doi "https://doi.org/10.1113/jphysiol.2012.238485" @default.
• W1568766475 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3487031" @default.
• W1568766475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22753545" @default.
• W1568766475 hasPublicationYear "2012" @default.
• W1568766475 type Work @default.
• W1568766475 sameAs 1568766475 @default.
• W1568766475 citedByCount "41" @default.
• W1568766475 countsByYear W15687664752012 @default.
• W1568766475 countsByYear W15687664752013 @default.
• W1568766475 countsByYear W15687664752014 @default.
• W1568766475 countsByYear W15687664752015 @default.
• W1568766475 countsByYear W15687664752016 @default.
• W1568766475 countsByYear W15687664752017 @default.
• W1568766475 countsByYear W15687664752018 @default.
• W1568766475 countsByYear W15687664752019 @default.
• W1568766475 countsByYear W15687664752020 @default.
• W1568766475 countsByYear W15687664752021 @default.
• W1568766475 countsByYear W15687664752022 @default.
• W1568766475 countsByYear W15687664752023 @default.
• W1568766475 crossrefType "journal-article" @default.
• W1568766475 hasAuthorship W1568766475A5024731647 @default.
• W1568766475 hasAuthorship W1568766475A5047239811 @default.
• W1568766475 hasAuthorship W1568766475A5047580780 @default.
• W1568766475 hasAuthorship W1568766475A5055505451 @default.
• W1568766475 hasAuthorship W1568766475A5059992473 @default.
• W1568766475 hasAuthorship W1568766475A5077060771 @default.
• W1568766475 hasBestOaLocation W15687664751 @default.
• W1568766475 hasConcept C105702510 @default.
• W1568766475 hasConcept C12554922 @default.
• W1568766475 hasConcept C126322002 @default.
• W1568766475 hasConcept C131453863 @default.
• W1568766475 hasConcept C134018914 @default.
• W1568766475 hasConcept C147944092 @default.
• W1568766475 hasConcept C15490471 @default.
• W1568766475 hasConcept C169760540 @default.
• W1568766475 hasConcept C170493617 @default.
• W1568766475 hasConcept C172659308 @default.
• W1568766475 hasConcept C185263204 @default.

• next