Matches in SemOpenAlex for { <https://semopenalex.org/work/W1568787298> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1568787298 endingPage "728" @default.
- W1568787298 startingPage "724" @default.
- W1568787298 abstract "Object The aim of the current study was to examine and compare the aftereffects of local high-frequency microstimulation through the recording electrode on the firing of neurons in the subthalamic nucleus (STN) and the substantia nigra pars reticulata (SNr) in patients undergoing surgery for deep brain stimulation. Deep brain stimulation has been playing an increasing role in the treatment of Parkinson disease, with the subthalamic nucleus (STN) being the preferred implantation target. Changes in cellular activity indicative of the borders of the STN are typically used during surgery to determine the extent of the STN and locate the optimal target, but in some cases borders may be difficult to identify. In this study the authors compared the effects of microstimulation in the SNr and STN. In previous studies they have shown that microstimulation in the internal globus pallidus, which is functionally similar to the SNr, inhibits firing, whereas similar microstimulation in the STN has minimal effect. The presence of inhibition in the SNr but not in the STN could be used as an additional criterion to help identify the location of the border between the STN and SNr. Methods Dual microelectrode recordings were performed during stereotactic surgery in 4 patients. Well-isolated high-amplitude units were stimulated extracellularly through the recording microelectrode with 0.5-second trains of high frequency (200 Hz) and low current (≤ 5 μA). Results In the majority (92%) of SNr neurons, this type of stimulation led to a period of inhibition lasting several hundreds of milliseconds following the end of the train. In contrast, only 1 neuron of 70 judged to be in the STN by other criteria was inhibited by this type of microstimulation, and this neuron was located at the ventral border of the STN. Conclusions These findings indicate that prolonged inhibition of firing following low-amplitude high-frequency microstimulation via the recording electrode is a consistent feature of almost all SNr neurons and rarely if ever occurs in STN neurons. This feature therefore provides a useful additional finding that can be used to help identify the border between the STN and SNr." @default.
- W1568787298 created "2016-06-24" @default.
- W1568787298 creator A5005752558 @default.
- W1568787298 creator A5021176150 @default.
- W1568787298 creator A5071124477 @default.
- W1568787298 creator A5072049382 @default.
- W1568787298 creator A5091526219 @default.
- W1568787298 date "2009-10-01" @default.
- W1568787298 modified "2023-09-25" @default.
- W1568787298 title "Microstimulation-induced inhibition as a tool to aid targeting the ventral border of the subthalamic nucleus" @default.
- W1568787298 cites W2324787148 @default.
- W1568787298 doi "https://doi.org/10.3171/2009.3.jns09111" @default.
- W1568787298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19408978" @default.
- W1568787298 hasPublicationYear "2009" @default.
- W1568787298 type Work @default.
- W1568787298 sameAs 1568787298 @default.
- W1568787298 citedByCount "26" @default.
- W1568787298 countsByYear W15687872982012 @default.
- W1568787298 countsByYear W15687872982013 @default.
- W1568787298 countsByYear W15687872982014 @default.
- W1568787298 countsByYear W15687872982015 @default.
- W1568787298 countsByYear W15687872982017 @default.
- W1568787298 countsByYear W15687872982018 @default.
- W1568787298 countsByYear W15687872982019 @default.
- W1568787298 countsByYear W15687872982020 @default.
- W1568787298 countsByYear W15687872982021 @default.
- W1568787298 countsByYear W15687872982022 @default.
- W1568787298 crossrefType "journal-article" @default.
- W1568787298 hasAuthorship W1568787298A5005752558 @default.
- W1568787298 hasAuthorship W1568787298A5021176150 @default.
- W1568787298 hasAuthorship W1568787298A5071124477 @default.
- W1568787298 hasAuthorship W1568787298A5072049382 @default.
- W1568787298 hasAuthorship W1568787298A5091526219 @default.
- W1568787298 hasBestOaLocation W15687872981 @default.
- W1568787298 hasConcept C111670793 @default.
- W1568787298 hasConcept C126322002 @default.
- W1568787298 hasConcept C147789679 @default.
- W1568787298 hasConcept C169760540 @default.
- W1568787298 hasConcept C17525397 @default.
- W1568787298 hasConcept C185592680 @default.
- W1568787298 hasConcept C24998067 @default.
- W1568787298 hasConcept C2777319143 @default.
- W1568787298 hasConcept C2778187257 @default.
- W1568787298 hasConcept C2778542668 @default.
- W1568787298 hasConcept C2778970358 @default.
- W1568787298 hasConcept C2779134260 @default.
- W1568787298 hasConcept C2779734285 @default.
- W1568787298 hasConcept C2780278869 @default.
- W1568787298 hasConcept C2780938664 @default.
- W1568787298 hasConcept C529278444 @default.
- W1568787298 hasConcept C71924100 @default.
- W1568787298 hasConcept C74254510 @default.
- W1568787298 hasConcept C86803240 @default.
- W1568787298 hasConceptScore W1568787298C111670793 @default.
- W1568787298 hasConceptScore W1568787298C126322002 @default.
- W1568787298 hasConceptScore W1568787298C147789679 @default.
- W1568787298 hasConceptScore W1568787298C169760540 @default.
- W1568787298 hasConceptScore W1568787298C17525397 @default.
- W1568787298 hasConceptScore W1568787298C185592680 @default.
- W1568787298 hasConceptScore W1568787298C24998067 @default.
- W1568787298 hasConceptScore W1568787298C2777319143 @default.
- W1568787298 hasConceptScore W1568787298C2778187257 @default.
- W1568787298 hasConceptScore W1568787298C2778542668 @default.
- W1568787298 hasConceptScore W1568787298C2778970358 @default.
- W1568787298 hasConceptScore W1568787298C2779134260 @default.
- W1568787298 hasConceptScore W1568787298C2779734285 @default.
- W1568787298 hasConceptScore W1568787298C2780278869 @default.
- W1568787298 hasConceptScore W1568787298C2780938664 @default.
- W1568787298 hasConceptScore W1568787298C529278444 @default.
- W1568787298 hasConceptScore W1568787298C71924100 @default.
- W1568787298 hasConceptScore W1568787298C74254510 @default.
- W1568787298 hasConceptScore W1568787298C86803240 @default.
- W1568787298 hasIssue "4" @default.
- W1568787298 hasLocation W15687872981 @default.
- W1568787298 hasLocation W15687872982 @default.
- W1568787298 hasOpenAccess W1568787298 @default.
- W1568787298 hasPrimaryLocation W15687872981 @default.
- W1568787298 hasRelatedWork W110291323 @default.
- W1568787298 hasRelatedWork W127062698 @default.
- W1568787298 hasRelatedWork W1568787298 @default.
- W1568787298 hasRelatedWork W1984336478 @default.
- W1568787298 hasRelatedWork W1988653062 @default.
- W1568787298 hasRelatedWork W1997422369 @default.
- W1568787298 hasRelatedWork W2047111146 @default.
- W1568787298 hasRelatedWork W2135680629 @default.
- W1568787298 hasRelatedWork W2398062905 @default.
- W1568787298 hasRelatedWork W337778128 @default.
- W1568787298 hasVolume "111" @default.
- W1568787298 isParatext "false" @default.
- W1568787298 isRetracted "false" @default.
- W1568787298 magId "1568787298" @default.
- W1568787298 workType "article" @default.