Matches in SemOpenAlex for { <https://semopenalex.org/work/W1568830051> ?p ?o ?g. }
- W1568830051 endingPage "18" @default.
- W1568830051 startingPage "1708" @default.
- W1568830051 abstract "To determine whether a nocturnal increase of ciliary process beta-adrenergic receptor responsiveness can explain the observation that timolol decreased the aqueous flow rate and intraocular pressure (IOP) during the night but not during the day in rabbits.Rabbits were housed in alternating 12-hour periods of light and dark. In vitro stimulation of tissue cyclic adenosine monophosphate (cAMP) levels by isoproterenol (ISO), vasoactive intestinal peptide (VIP), pituitary adenylate cyclase activating polypeptide (PACAP), or a soluble derivative of forskolin (sFSK) was measured in ciliary processes harvested at mid-light phase and early and late dark phase. Inhibition of ISO and VIP stimulation of ciliary process cAMP by an alpha 2-adrenergic agonist and maximal binding of [125I]I-pindolol, [125I]I-VIP, and [125I]I-PACAP in ciliary process membranes were measured at the same three times.Although there may have been a nocturnal increase in the sensitivity of ciliary process cAMP levels to stimulation by ISO, this was not observed consistently, VIP, but not PACAP, stimulation increased at night, but there was no change in the response to sFSK. Inhibition by apraclonidine of elevated ciliary process cAMP levels was constant at all three times. Ligand-binding studies showed little change in ciliary process beta-adrenergic, VIP-, or PACAP-receptor levels at the three times.There is no convincing evidence for a nocturnal increase in beta-adrenergic receptor sensitivity in rabbit ciliary processes that could explain the difference between day and night effects of timolol on aqueous flow and IOP." @default.
- W1568830051 created "2016-06-24" @default.
- W1568830051 creator A5004527591 @default.
- W1568830051 creator A5007316747 @default.
- W1568830051 creator A5018300331 @default.
- W1568830051 creator A5045787687 @default.
- W1568830051 date "1997-08-01" @default.
- W1568830051 modified "2023-09-27" @default.
- W1568830051 title "Response and level of beta-adrenergic, vasoactive intestinal peptide, and PACAP receptors during the circadian cycle." @default.
- W1568830051 cites W114204161 @default.
- W1568830051 cites W127182960 @default.
- W1568830051 cites W142266519 @default.
- W1568830051 cites W1497519474 @default.
- W1568830051 cites W1507115169 @default.
- W1568830051 cites W1517340966 @default.
- W1568830051 cites W157019730 @default.
- W1568830051 cites W1582695838 @default.
- W1568830051 cites W1775749144 @default.
- W1568830051 cites W1945832201 @default.
- W1568830051 cites W1984999784 @default.
- W1568830051 cites W198583322 @default.
- W1568830051 cites W1994220974 @default.
- W1568830051 cites W1997975361 @default.
- W1568830051 cites W2001323421 @default.
- W1568830051 cites W2001786765 @default.
- W1568830051 cites W2009496581 @default.
- W1568830051 cites W2014149333 @default.
- W1568830051 cites W2018953089 @default.
- W1568830051 cites W2020438080 @default.
- W1568830051 cites W2022241854 @default.
- W1568830051 cites W2033146455 @default.
- W1568830051 cites W2037073490 @default.
- W1568830051 cites W2040808883 @default.
- W1568830051 cites W2043813981 @default.
- W1568830051 cites W2060702151 @default.
- W1568830051 cites W2064215179 @default.
- W1568830051 cites W2074327002 @default.
- W1568830051 cites W2103386533 @default.
- W1568830051 cites W2115521327 @default.
- W1568830051 cites W2126457298 @default.
- W1568830051 cites W2128635872 @default.
- W1568830051 cites W2151234310 @default.
- W1568830051 cites W2159238993 @default.
- W1568830051 cites W2163603344 @default.
- W1568830051 cites W2269886241 @default.
- W1568830051 cites W45441874 @default.
- W1568830051 cites W59816155 @default.
- W1568830051 cites W83486352 @default.
- W1568830051 cites W83534692 @default.
- W1568830051 cites W85595390 @default.
- W1568830051 cites W94284799 @default.
- W1568830051 cites W20674265 @default.
- W1568830051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9286259" @default.
- W1568830051 hasPublicationYear "1997" @default.
- W1568830051 type Work @default.
- W1568830051 sameAs 1568830051 @default.
- W1568830051 citedByCount "1" @default.
- W1568830051 crossrefType "journal-article" @default.
- W1568830051 hasAuthorship W1568830051A5004527591 @default.
- W1568830051 hasAuthorship W1568830051A5007316747 @default.
- W1568830051 hasAuthorship W1568830051A5018300331 @default.
- W1568830051 hasAuthorship W1568830051A5045787687 @default.
- W1568830051 hasConcept C118303440 @default.
- W1568830051 hasConcept C126322002 @default.
- W1568830051 hasConcept C134018914 @default.
- W1568830051 hasConcept C169760540 @default.
- W1568830051 hasConcept C170493617 @default.
- W1568830051 hasConcept C185592680 @default.
- W1568830051 hasConcept C24998067 @default.
- W1568830051 hasConcept C2776668983 @default.
- W1568830051 hasConcept C2778073030 @default.
- W1568830051 hasConcept C2778434524 @default.
- W1568830051 hasConcept C2778499207 @default.
- W1568830051 hasConcept C2778527774 @default.
- W1568830051 hasConcept C2778938600 @default.
- W1568830051 hasConcept C2779105803 @default.
- W1568830051 hasConcept C2779276759 @default.
- W1568830051 hasConcept C40465926 @default.
- W1568830051 hasConcept C71924100 @default.
- W1568830051 hasConcept C8330315 @default.
- W1568830051 hasConcept C86803240 @default.
- W1568830051 hasConceptScore W1568830051C118303440 @default.
- W1568830051 hasConceptScore W1568830051C126322002 @default.
- W1568830051 hasConceptScore W1568830051C134018914 @default.
- W1568830051 hasConceptScore W1568830051C169760540 @default.
- W1568830051 hasConceptScore W1568830051C170493617 @default.
- W1568830051 hasConceptScore W1568830051C185592680 @default.
- W1568830051 hasConceptScore W1568830051C24998067 @default.
- W1568830051 hasConceptScore W1568830051C2776668983 @default.
- W1568830051 hasConceptScore W1568830051C2778073030 @default.
- W1568830051 hasConceptScore W1568830051C2778434524 @default.
- W1568830051 hasConceptScore W1568830051C2778499207 @default.
- W1568830051 hasConceptScore W1568830051C2778527774 @default.
- W1568830051 hasConceptScore W1568830051C2778938600 @default.
- W1568830051 hasConceptScore W1568830051C2779105803 @default.
- W1568830051 hasConceptScore W1568830051C2779276759 @default.
- W1568830051 hasConceptScore W1568830051C40465926 @default.
- W1568830051 hasConceptScore W1568830051C71924100 @default.