Matches in SemOpenAlex for { <https://semopenalex.org/work/W1568851820> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W1568851820 endingPage "458" @default.
- W1568851820 startingPage "453" @default.
- W1568851820 abstract "The effects of the protein cesalin were studied to determine the site of its toxic action in KB cells for which the ID50 is 0.9 pg/ml. Several effects have been noted: (i) respiration in KB cells was reduced by greater than 50% within 1 h after cesalin addition, which could not be explained on the basis of mitochondrial damage or from elevated intracellular ATP levels, since these did not rise significantly until about 3 h after cesalin addition; (ii) both DNA and RNA synthesis were inhibited, starting about 3 h after addition of cesalin to KB cells, but the transport of nucleosides and amino acids does not appear to be affected; (iii) no decrease is observed in protein synthesis for at least 5 to 6 h; (iv) cesalin can inhibit DNA synthesis and mitotic division independently of one another. The interaction of cesalin with the cell surface is rapid and after 5 min at 37 degrees C less than 10% of treated cells can be rescued by addition of excess antiserum to cesalin. The cell surface receptors are exposed throughout the cell cycle and the toxicity of cesalin is not restricted to a particular phase of this cycle." @default.
- W1568851820 created "2016-06-24" @default.
- W1568851820 creator A5015580490 @default.
- W1568851820 creator A5063407886 @default.
- W1568851820 date "1979-01-01" @default.
- W1568851820 modified "2023-10-01" @default.
- W1568851820 title "Biological effects of cesalin, an anti-tumor protein, on cultured mammalian cells." @default.
- W1568851820 cites W1532520741 @default.
- W1568851820 cites W1964275197 @default.
- W1568851820 cites W1991342668 @default.
- W1568851820 cites W1992239258 @default.
- W1568851820 cites W2022192917 @default.
- W1568851820 cites W2028479043 @default.
- W1568851820 cites W2034494883 @default.
- W1568851820 cites W2053180358 @default.
- W1568851820 cites W2072335894 @default.
- W1568851820 cites W2079938883 @default.
- W1568851820 cites W2080144126 @default.
- W1568851820 cites W2091667646 @default.
- W1568851820 cites W2096725836 @default.
- W1568851820 cites W2243489036 @default.
- W1568851820 doi "https://doi.org/10.1016/s0021-9258(17)37939-5" @default.
- W1568851820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/762073" @default.
- W1568851820 hasPublicationYear "1979" @default.
- W1568851820 type Work @default.
- W1568851820 sameAs 1568851820 @default.
- W1568851820 citedByCount "11" @default.
- W1568851820 countsByYear W15688518202018 @default.
- W1568851820 countsByYear W15688518202019 @default.
- W1568851820 crossrefType "journal-article" @default.
- W1568851820 hasAuthorship W1568851820A5015580490 @default.
- W1568851820 hasAuthorship W1568851820A5063407886 @default.
- W1568851820 hasBestOaLocation W15688518201 @default.
- W1568851820 hasConcept C153911025 @default.
- W1568851820 hasConcept C185592680 @default.
- W1568851820 hasConcept C3020616263 @default.
- W1568851820 hasConcept C502942594 @default.
- W1568851820 hasConcept C55493867 @default.
- W1568851820 hasConcept C86803240 @default.
- W1568851820 hasConcept C95444343 @default.
- W1568851820 hasConceptScore W1568851820C153911025 @default.
- W1568851820 hasConceptScore W1568851820C185592680 @default.
- W1568851820 hasConceptScore W1568851820C3020616263 @default.
- W1568851820 hasConceptScore W1568851820C502942594 @default.
- W1568851820 hasConceptScore W1568851820C55493867 @default.
- W1568851820 hasConceptScore W1568851820C86803240 @default.
- W1568851820 hasConceptScore W1568851820C95444343 @default.
- W1568851820 hasIssue "2" @default.
- W1568851820 hasLocation W15688518201 @default.
- W1568851820 hasOpenAccess W1568851820 @default.
- W1568851820 hasPrimaryLocation W15688518201 @default.
- W1568851820 hasRelatedWork W1531601525 @default.
- W1568851820 hasRelatedWork W1972570265 @default.
- W1568851820 hasRelatedWork W1990781990 @default.
- W1568851820 hasRelatedWork W2069205357 @default.
- W1568851820 hasRelatedWork W2314643286 @default.
- W1568851820 hasRelatedWork W2435174528 @default.
- W1568851820 hasRelatedWork W2748952813 @default.
- W1568851820 hasRelatedWork W2899084033 @default.
- W1568851820 hasRelatedWork W2948807893 @default.
- W1568851820 hasRelatedWork W2778153218 @default.
- W1568851820 hasVolume "254" @default.
- W1568851820 isParatext "false" @default.
- W1568851820 isRetracted "false" @default.
- W1568851820 magId "1568851820" @default.
- W1568851820 workType "article" @default.