FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1568859360> ?p ?o ?g. }

• W1568859360 abstract "Urinary pharmacokinetic methods have been identified to determine the relative lung and systemic bioavailability after an inhalation. We have extended this methodology to inhaled beclometasone dipropionate (BDP).Ethics Committee approval was obtained and all subjects gave consent. Twelve healthy volunteers received randomized doses, separated by >7 days, of 2000 µg BDP solution with (OralC) and without (Oral) 5 g oral charcoal, 10,100 µg inhalations from a Qvar(®) Easibreathe metered dose inhaler (pMDI) with (QvarC) and without (Qvar) oral charcoal and eight 250 µg inhalations from a Clenil(®) pMDI (Clenil). Subjects provided urine samples at 0, 0.5, 1, 2, 3, 5, 8, 12 and 24 h post study dose. Urinary concentrations of BDP and its metabolites, beclometasone-17-monopropionate (17-BMP) and beclometasone (BOH) were measured.No BDP, 17-BMP or BOH were detected in any samples post OralC dosing. Post oral dosing no BDP was detected in all urine samples and no 17-BMP or BOH was excreted in the first 30 min. Significantly more (P < 0.001) BDP, 17-BMP and BOH were excreted in the first 30 min and the cumulative 24 h urinary excretions post Qvar and Clenil compared with Oral. The mean ratio (90% confidence interval) of the 30 min urinary excretions for Qvar compared with Clenil was 231.4 (209.6, 255.7) %.The urinary pharmacokinetic methodology to determine the relative lung and systemic bioavailability post inhalation, using 30 min and cumulative 24 h post inhalation samples, applies to BDP. The ratio between Qvar and Clenil is consistent with related clinical and lung deposition studies." @default.
• W1568859360 created "2016-06-24" @default.
• W1568859360 creator A5026990554 @default.
• W1568859360 creator A5030087459 @default.
• W1568859360 creator A5047979811 @default.
• W1568859360 date "2012-08-06" @default.
• W1568859360 modified "2023-09-28" @default.
• W1568859360 title "Urinary pharmacokinetic methodology to determine the relative lung bioavailability of inhaled beclometasone dipropionate" @default.
• W1568859360 cites W1508938702 @default.
• W1568859360 cites W1592626078 @default.
• W1568859360 cites W1967704055 @default.
• W1568859360 cites W1977497452 @default.
• W1568859360 cites W1979404026 @default.
• W1568859360 cites W1984702937 @default.
• W1568859360 cites W1986186916 @default.
• W1568859360 cites W2006545949 @default.
• W1568859360 cites W2032294601 @default.
• W1568859360 cites W2043162795 @default.
• W1568859360 cites W2045742634 @default.
• W1568859360 cites W2057220993 @default.
• W1568859360 cites W2065077947 @default.
• W1568859360 cites W2096296338 @default.
• W1568859360 cites W2098680476 @default.
• W1568859360 cites W2106546427 @default.
• W1568859360 cites W2107462455 @default.
• W1568859360 cites W2111093159 @default.
• W1568859360 cites W2115125184 @default.
• W1568859360 cites W2117401654 @default.
• W1568859360 cites W2118957675 @default.
• W1568859360 cites W2139148381 @default.
• W1568859360 cites W2151913018 @default.
• W1568859360 cites W2156212492 @default.
• W1568859360 doi "https://doi.org/10.1111/j.1365-2125.2012.04210.x" @default.
• W1568859360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3477347" @default.
• W1568859360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22299644" @default.
• W1568859360 hasPublicationYear "2012" @default.
• W1568859360 type Work @default.
• W1568859360 sameAs 1568859360 @default.
• W1568859360 citedByCount "8" @default.
• W1568859360 countsByYear W15688593602015 @default.
• W1568859360 countsByYear W15688593602016 @default.
• W1568859360 countsByYear W15688593602018 @default.
• W1568859360 countsByYear W15688593602019 @default.
• W1568859360 countsByYear W15688593602020 @default.
• W1568859360 countsByYear W15688593602021 @default.
• W1568859360 countsByYear W15688593602022 @default.
• W1568859360 crossrefType "journal-article" @default.
• W1568859360 hasAuthorship W1568859360A5026990554 @default.
• W1568859360 hasAuthorship W1568859360A5030087459 @default.
• W1568859360 hasAuthorship W1568859360A5047979811 @default.
• W1568859360 hasBestOaLocation W15688593602 @default.
• W1568859360 hasConcept C112705442 @default.
• W1568859360 hasConcept C126322002 @default.
• W1568859360 hasConcept C181389837 @default.
• W1568859360 hasConcept C2776178081 @default.
• W1568859360 hasConcept C2776954882 @default.
• W1568859360 hasConcept C2777714996 @default.
• W1568859360 hasConcept C2777992530 @default.
• W1568859360 hasConcept C42219234 @default.
• W1568859360 hasConcept C71924100 @default.
• W1568859360 hasConcept C77411442 @default.
• W1568859360 hasConcept C98274493 @default.
• W1568859360 hasConceptScore W1568859360C112705442 @default.
• W1568859360 hasConceptScore W1568859360C126322002 @default.
• W1568859360 hasConceptScore W1568859360C181389837 @default.
• W1568859360 hasConceptScore W1568859360C2776178081 @default.
• W1568859360 hasConceptScore W1568859360C2776954882 @default.
• W1568859360 hasConceptScore W1568859360C2777714996 @default.
• W1568859360 hasConceptScore W1568859360C2777992530 @default.
• W1568859360 hasConceptScore W1568859360C42219234 @default.
• W1568859360 hasConceptScore W1568859360C71924100 @default.
• W1568859360 hasConceptScore W1568859360C77411442 @default.
• W1568859360 hasConceptScore W1568859360C98274493 @default.
• W1568859360 hasLocation W15688593601 @default.
• W1568859360 hasLocation W15688593602 @default.
• W1568859360 hasLocation W15688593603 @default.
• W1568859360 hasLocation W15688593604 @default.
• W1568859360 hasOpenAccess W1568859360 @default.
• W1568859360 hasPrimaryLocation W15688593601 @default.
• W1568859360 hasRelatedWork W1508938702 @default.
• W1568859360 hasRelatedWork W1967989858 @default.
• W1568859360 hasRelatedWork W1980965266 @default.
• W1568859360 hasRelatedWork W1991582637 @default.
• W1568859360 hasRelatedWork W1995476007 @default.
• W1568859360 hasRelatedWork W2004782061 @default.
• W1568859360 hasRelatedWork W2018663633 @default.
• W1568859360 hasRelatedWork W2047893816 @default.
• W1568859360 hasRelatedWork W2054023362 @default.
• W1568859360 hasRelatedWork W2054962915 @default.
• W1568859360 hasRelatedWork W2076459348 @default.
• W1568859360 hasRelatedWork W2080409752 @default.
• W1568859360 hasRelatedWork W2086220988 @default.
• W1568859360 hasRelatedWork W2094533034 @default.
• W1568859360 hasRelatedWork W2098680476 @default.
• W1568859360 hasRelatedWork W2133660309 @default.
• W1568859360 hasRelatedWork W2139148381 @default.
• W1568859360 hasRelatedWork W2184365037 @default.
• W1568859360 hasRelatedWork W2414217085 @default.
• W1568859360 hasRelatedWork W2417018649 @default.
• W1568859360 isParatext "false" @default.

• next