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- W1568875511 abstract "This chapter discusses molecular evolution of RNA and optimization of RNA properties and models to study the evolution of RNA. The first successful attempts to study RNA evolution in vitro were carried out in the late sixties by Sol Spiegelman and his group at Columbia University. They made use of an RNA replicase isolated from Escherichia coli cells infected by the RNA bacteriophage Qβ and prepared a medium for replication by adding the four ribonucleoside triphosphates (GTP, ATP, CTP, and UTP) in a suitable buffer solution. Qβ RNA, when transferred into this medium, instantaneously started to replicate. Evolutionary experiments were carried out by means of the serial transfer technique. Evolutionary methods were also used to modify catalytic RNA molecules: Group I introns were trained to cleave DNA instead of their genuine RNA substrates or they were reprogrammed to work in presence of Ca 2+ rather than Mg 2+ cations. The RNA amplification system used in these experiments is closely related to the polymerase chain reaction (PCR) based assay. The desire to create RNA molecules with predefined properties and to optimize their efficiencies and specificities has led to a new technique called “evolutionary biotechnology” or “applied molecular evolution.”" @default.
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- W1568875511 date "1998-01-01" @default.
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- W1568875511 title "Evolution in an RNA World" @default.
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- W1568875511 doi "https://doi.org/10.1016/s1874-5660(98)80006-3" @default.
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