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- W1568890765 abstract "Genetically encoded ratiometric sensors can providevaluable mechanistic understanding of biological systems.Characterization of cellular response of these sensors is the firststep in validating their use. Here, we characterize the response ofa genetically encoded H₂O₂ sensor, HyPer, expressed in HeLa cells.Using quantitative fluorescence microscopy, we found significantheterogeneity in HyPer response among the cell population. Furtheranalysis showed that the variation in HyPer response was dependenton expression of HyPer protein as well as on cell cycle phase.Cells with higher levels of expressed HyPer protein showed astronger HyPer response to H₂O₂. Cells synchronized in S-phaseshowed a weaker HyPer response than unsynchronized cells. It wasdetermined that this weaker response could be a function of higherantioxidant capacity in S-phase cells. The dependence of HyPerresponse on these factors needs to be accounted for to avoidexperimental artifacts." @default.
- W1568890765 created "2016-06-24" @default.
- W1568890765 creator A5070297649 @default.
- W1568890765 date "2013-01-01" @default.
- W1568890765 modified "2023-09-27" @default.
- W1568890765 title "Heterogeneity in the population response of a human cell line to hydrogen peroxide as measured by a genetically encoded sensor" @default.
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