Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569001872> ?p ?o ?g. }
- W1569001872 abstract "Cellular membranes have complex lipid and protein structures that are laterally organized for optimized molecular recognition and signal transduction processes. Knowledge of nanometer-scale lateral organization and its function is of great importance in the analysis of receptor-based signaling. In model membranes, we studied in detail the chemical and physical factors which result in lateral organization of lipids and lipid-mediated protein sequestration into signaling domains. In biological membranes, we mapped the location and follow the dynamic activity of specific membrane proteins involved in the immunological response of mast cells. These studies were enabled by our development of advanced imaging methods that provided both high spatial resolution and sensitivity to dynamical processes. Our technical approach was to combine the high sensitivity and time resolution of fluorescence imaging with the high lateral resolution of atomic force microscopy (AFM). Simultaneous fluorescence and AFM imaging allows correlation of the distribution and dynamic activity of specific biomolecules via fluorescence labeling with complete topographic information of the membrane. Overall, our unique imaging capabilities enabled us to examine membrane structure and function with much greater detail than was previously possible and thus provide a better understanding of cellular signaling." @default.
- W1569001872 created "2016-06-24" @default.
- W1569001872 creator A5008157486 @default.
- W1569001872 creator A5020935313 @default.
- W1569001872 creator A5043496898 @default.
- W1569001872 creator A5080696258 @default.
- W1569001872 date "2006-10-01" @default.
- W1569001872 modified "2023-09-24" @default.
- W1569001872 title "Studies of signaling domains in model and biological membranes through advanced imaging techniques: final report." @default.
- W1569001872 cites W1031262280 @default.
- W1569001872 cites W1195340218 @default.
- W1569001872 cites W1526473234 @default.
- W1569001872 cites W1563458114 @default.
- W1569001872 cites W1566007029 @default.
- W1569001872 cites W1630241876 @default.
- W1569001872 cites W1635401440 @default.
- W1569001872 cites W1965530119 @default.
- W1569001872 cites W1967816643 @default.
- W1569001872 cites W1968471171 @default.
- W1569001872 cites W1968786790 @default.
- W1569001872 cites W1969073916 @default.
- W1569001872 cites W1976786825 @default.
- W1569001872 cites W1977471961 @default.
- W1569001872 cites W1978482234 @default.
- W1569001872 cites W1979552135 @default.
- W1569001872 cites W1979607911 @default.
- W1569001872 cites W1986752048 @default.
- W1569001872 cites W1989792520 @default.
- W1569001872 cites W1991655565 @default.
- W1569001872 cites W1992436206 @default.
- W1569001872 cites W1994333574 @default.
- W1569001872 cites W1995515519 @default.
- W1569001872 cites W1997900152 @default.
- W1569001872 cites W1998697778 @default.
- W1569001872 cites W1999639967 @default.
- W1569001872 cites W2001642480 @default.
- W1569001872 cites W2010549225 @default.
- W1569001872 cites W2017038627 @default.
- W1569001872 cites W2018054206 @default.
- W1569001872 cites W2019164398 @default.
- W1569001872 cites W2020785009 @default.
- W1569001872 cites W2021211941 @default.
- W1569001872 cites W2022289767 @default.
- W1569001872 cites W2023008409 @default.
- W1569001872 cites W2023235169 @default.
- W1569001872 cites W2023607661 @default.
- W1569001872 cites W2023965621 @default.
- W1569001872 cites W2023993671 @default.
- W1569001872 cites W2025529482 @default.
- W1569001872 cites W2029705670 @default.
- W1569001872 cites W2030794991 @default.
- W1569001872 cites W2033036299 @default.
- W1569001872 cites W2034122210 @default.
- W1569001872 cites W2034506702 @default.
- W1569001872 cites W2036106737 @default.
- W1569001872 cites W2038576151 @default.
- W1569001872 cites W2038780460 @default.
- W1569001872 cites W2042594035 @default.
- W1569001872 cites W2048191546 @default.
- W1569001872 cites W2048668901 @default.
- W1569001872 cites W2057809752 @default.
- W1569001872 cites W2057973387 @default.
- W1569001872 cites W2063036108 @default.
- W1569001872 cites W2067594620 @default.
- W1569001872 cites W2068237765 @default.
- W1569001872 cites W2072677086 @default.
- W1569001872 cites W2074567180 @default.
- W1569001872 cites W2075617262 @default.
- W1569001872 cites W2076227275 @default.
- W1569001872 cites W2077433673 @default.
- W1569001872 cites W2080643927 @default.
- W1569001872 cites W2081304429 @default.
- W1569001872 cites W2081769662 @default.
- W1569001872 cites W2083683885 @default.
- W1569001872 cites W2083707276 @default.
- W1569001872 cites W2087962646 @default.
- W1569001872 cites W2088720601 @default.
- W1569001872 cites W2093315204 @default.
- W1569001872 cites W2094542222 @default.
- W1569001872 cites W2099771419 @default.
- W1569001872 cites W2099906733 @default.
- W1569001872 cites W2104139776 @default.
- W1569001872 cites W2105976188 @default.
- W1569001872 cites W2106217238 @default.
- W1569001872 cites W2107885482 @default.
- W1569001872 cites W2108598406 @default.
- W1569001872 cites W2109534784 @default.
- W1569001872 cites W2111679811 @default.
- W1569001872 cites W2115781573 @default.
- W1569001872 cites W2116856926 @default.
- W1569001872 cites W2121936687 @default.
- W1569001872 cites W2122882997 @default.
- W1569001872 cites W2135371328 @default.
- W1569001872 cites W2136795628 @default.
- W1569001872 cites W2141367941 @default.
- W1569001872 cites W2143246496 @default.
- W1569001872 cites W2146439388 @default.
- W1569001872 cites W2151137395 @default.
- W1569001872 cites W2151991230 @default.
- W1569001872 cites W2160679445 @default.