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- W1569006374 abstract "Strains have been isolated which are diploid for about one-third of the linkage map of E. coli, including a locus Rarg which controls repressibility of the enzymes of arginine biosynthesis. In Rarg+/Rarg− merodiploids, isolated from a cross of a repressible (Rarg+) double-male donor with a non-repressible (Rarg−) recipient, arginine is able to repress enzyme formation, showing that repressibility, as in Rarg+/Rarg− merozygotes, is a dominant trait. In interpreting this finding it is suggested that the gene Rarg+ controls the production of a specific repressor in the cytoplasm. This interpretation has been given previously for similar findings in other metabolic pathways, notably for the control of the enzymes of lactose fermentation and of histidine and tryptophan biosynthesis. The term regulon is proposed to describe such a system in which the production of all enzymes can be controlled by a single repressor substance. Two types of regulons can be distinguished, those in which the structural genes for the enzymes are adjacent to each other (histidine, tryptophan) and which thus consist of single operons, and those in which they are not (arginine) and which thus consist of several operons." @default.
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- W1569006374 date "1964-03-01" @default.
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- W1569006374 title "Studies on the mechanism of repression of arginine biosynthesis in Escherichia coli" @default.
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- W1569006374 doi "https://doi.org/10.1016/s0022-2836(64)80200-x" @default.
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