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• W1569007332 abstract "Publisher Summary This chapter discusses studies that analyze sedatives, hypnotics, anticonvulsants, and general anesthetics. Sleep laboratory studies on lorazepam (WY 4036) showed that this compound depresses REM sleep but there is no rebound increase in REM during the post-drug nights. Stage 4 sleep was not decreased by lorazepam. No changes were seen in clinical laboratory studies or physical examinations. S-1530, the 1-methyl derivative of nitrazepam, a marketed hypnotic agent, was shown to have both antianxiety and hypnotic activity clinically. In animals, S-1530 was found to be more potent than either nitrazepam or diazepam as a muscle relaxant, anticonvulsant, and “sleep inducer.” CS-370 was found in the process of screening derivatives of the benzodiazepine derivative, oxazolam. This compound was more potent than oxazolam in laboratory tests and had a lower toxicity than does diazepam. The 2-monofluoromethyl analog of methaqualone was reported to be a more potent hypnotic agent than methaqualone with a lower toxicity. Two oxazolinone derivatives were found to exhibit sedation and muscle relaxation. Pharmacological studies with a new indole alkaloid, rugulovasine showed that the alkaloid depressed spontaneous motor activity, prolonged the duration of loss of righting reflex caused by barbiturate, and enhanced the similar potentiating effect of reserpine in mice." @default.
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• W1569007332 date "1972-01-01" @default.
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• W1569007332 title "Chapter 4. Sedatives, Hypnotics, Anticonvulsants and General Anesthetics" @default.
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• W1569007332 doi "https://doi.org/10.1016/s0065-7743(08)60799-x" @default.
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