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- W156900772 abstract "Striatin is a scaffold protein that associates with caveolin and calmodulin; key regulators of excitation-contraction coupling in the heart. The aim of the present study was to probe for a potential role for striatin in regulating calcium homeostasis in cardiomyocytes. Our findings indicate that striatin is expressed in rat hearts (cardiomyocytes enriched fraction) with a higher expression level in neonates vs adults. Protein-protein interaction assays revealed that, in the heart, striatin associates with calmodulin as well as caveolin-1 and caveolin-3 (muscle specific isoform). It was notable that the interaction between striatin and calmodulin was calcium sensitive: while calcium chloride (2 mM) showed robust pulldown of striatin with calmodulin, the calcium chelator EGTA (1 mM) attenuated this interaction. Moreover, KCl-induced intracellular calcium [Ca2+]i increase was sustained in cardiomyocytes overexpressing striatin (adenoviral delivery) while [Ca2+]i returned to near basal levels in control cardiomyocytes (non-target adenovirus). Collectively, our data indicate that striatin is expressed in cardiomyocytes and that it may play a role in maintaining [Ca2+]i homeostasis. This suggests that striatin may be involved in modulating cardiac excitation-contraction coupling and emerges as a novel target for therapeutic strategies in cardiac diseases." @default.
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- W156900772 date "2012-04-01" @default.
- W156900772 modified "2023-09-27" @default.
- W156900772 title "Striatin is a novel regulator of calcium homeostasis in cardiomyocytes" @default.
- W156900772 doi "https://doi.org/10.1096/fasebj.26.1_supplement.lb620" @default.
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