Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569008617> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W1569008617 endingPage "2544" @default.
- W1569008617 startingPage "2539" @default.
- W1569008617 abstract "The role of molecular mimicry in the spondyloarthropathies was investigated with respect to the epitopes involved. mAb were produced against a synthetic peptide whose sequence was derived from a polymorphic region of the HLA-B27 molecule (amino acids 63-83). Two antibodies (J7F2 and H2B6) were selected for study on the basis of their ability to react with bacterial envelope proteins (ELISA) and B27-positive cells (immunofluorescence). J7F2 reacted preferentially with B27-positive cells and neither antibody reacted with MHC class I negative cells. Based on SDS-PAGE blot analysis of bacterial envelope proteins, the pattern of reactivity for both antibodies (against 36- and 19-kDa proteins) was the same as that for a third monoclonal produced against bacterial envelope and reactive with B27-positive cells. This apparent epitope similarity was investigated by using synthetic peptides to inhibit binding of the monoclonals. The B27 synthetic peptide and a smaller peptide derived from it were efficient inhibitors of antipeptide and antibacterial antibody binding to bacterial Ag and B27-positive cells. These studies provide insight into the molecular basis of cross-reactivity between bacterial proteins and MHC class I molecules." @default.
- W1569008617 created "2016-06-24" @default.
- W1569008617 creator A5025939294 @default.
- W1569008617 creator A5061292298 @default.
- W1569008617 date "1990-10-15" @default.
- W1569008617 modified "2023-10-12" @default.
- W1569008617 title "Monoclonal antibodies against an HLA-B27-derived peptide react with an epitope present on bacterial proteins." @default.
- W1569008617 doi "https://doi.org/10.4049/jimmunol.145.8.2539" @default.
- W1569008617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1698856" @default.
- W1569008617 hasPublicationYear "1990" @default.
- W1569008617 type Work @default.
- W1569008617 sameAs 1569008617 @default.
- W1569008617 citedByCount "8" @default.
- W1569008617 crossrefType "journal-article" @default.
- W1569008617 hasAuthorship W1569008617A5025939294 @default.
- W1569008617 hasAuthorship W1569008617A5061292298 @default.
- W1569008617 hasBestOaLocation W15690086171 @default.
- W1569008617 hasConcept C104317684 @default.
- W1569008617 hasConcept C147483822 @default.
- W1569008617 hasConcept C153911025 @default.
- W1569008617 hasConcept C159654299 @default.
- W1569008617 hasConcept C167625842 @default.
- W1569008617 hasConcept C185592680 @default.
- W1569008617 hasConcept C195616568 @default.
- W1569008617 hasConcept C203014093 @default.
- W1569008617 hasConcept C2777119779 @default.
- W1569008617 hasConcept C2778236600 @default.
- W1569008617 hasConcept C2779281246 @default.
- W1569008617 hasConcept C542903549 @default.
- W1569008617 hasConcept C55493867 @default.
- W1569008617 hasConcept C86803240 @default.
- W1569008617 hasConceptScore W1569008617C104317684 @default.
- W1569008617 hasConceptScore W1569008617C147483822 @default.
- W1569008617 hasConceptScore W1569008617C153911025 @default.
- W1569008617 hasConceptScore W1569008617C159654299 @default.
- W1569008617 hasConceptScore W1569008617C167625842 @default.
- W1569008617 hasConceptScore W1569008617C185592680 @default.
- W1569008617 hasConceptScore W1569008617C195616568 @default.
- W1569008617 hasConceptScore W1569008617C203014093 @default.
- W1569008617 hasConceptScore W1569008617C2777119779 @default.
- W1569008617 hasConceptScore W1569008617C2778236600 @default.
- W1569008617 hasConceptScore W1569008617C2779281246 @default.
- W1569008617 hasConceptScore W1569008617C542903549 @default.
- W1569008617 hasConceptScore W1569008617C55493867 @default.
- W1569008617 hasConceptScore W1569008617C86803240 @default.
- W1569008617 hasIssue "8" @default.
- W1569008617 hasLocation W15690086171 @default.
- W1569008617 hasLocation W15690086172 @default.
- W1569008617 hasOpenAccess W1569008617 @default.
- W1569008617 hasPrimaryLocation W15690086171 @default.
- W1569008617 hasRelatedWork W1604248381 @default.
- W1569008617 hasRelatedWork W1999614011 @default.
- W1569008617 hasRelatedWork W2000190543 @default.
- W1569008617 hasRelatedWork W2038852982 @default.
- W1569008617 hasRelatedWork W2059923545 @default.
- W1569008617 hasRelatedWork W2109711258 @default.
- W1569008617 hasRelatedWork W2162389703 @default.
- W1569008617 hasRelatedWork W2320990282 @default.
- W1569008617 hasRelatedWork W2386118910 @default.
- W1569008617 hasRelatedWork W2400620861 @default.
- W1569008617 hasVolume "145" @default.
- W1569008617 isParatext "false" @default.
- W1569008617 isRetracted "false" @default.
- W1569008617 magId "1569008617" @default.
- W1569008617 workType "article" @default.