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- W1569010293 abstract "Serine/threonine kinases of the nuclear Dbf2-related (NDR) family are highlyconserved throughout the eukaryotic world. Members of this kinase family areimplicated in various aspects of the regulation of cell division and cell morphology. Ithas been shown that the function of several NDR kinases is dependent on proteins ofthe Mob (MPS one binder) family. MOB proteins are highly conserved throughout theeukaryotic world as well, which indicates the existence of a novel conserved signallingpathway.The current work focuses on the mechanism of activation of human NDR kinase bythe human MOB1 protein. hMOB1 directly activates NDR by binding to the Nterminaldomain of NDR, thereby hMOB1 acts as a kinase activating subunit of NDRkinase. The binding induces the release of an autoinhibition caused by anautoinhibitory sequence (AIS) and leads to increased phosphorylation of NDR kinaseon the two important regulatory phosphorylation sites Ser-281 and Thr-444." @default.
- W1569010293 created "2016-06-24" @default.
- W1569010293 creator A5039683116 @default.
- W1569010293 date "2005-01-01" @default.
- W1569010293 modified "2023-09-27" @default.
- W1569010293 title "Mechanism of activation of NDR protein kinase by the HMOB1 protein" @default.
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