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- W1569013957 abstract "In vivo studies of brain exposure are discussed in this chapter. First, the core methods used for these studies are summarized. Next, the chapter presents examples of the research questions for which in vivo brain studies provide data. It also highlights how these data are integrated with other data. The main product of in vivo brain studies is the total brain concentrations of a drug candidate at time points, which, in combination with in vitro and in silico methods, provides unbound drug concentrations (Cu,b), brain PK, and a PK/PD model. Following early in vitro biology studies with receptor-or cell-based assays, drug discovery teams may obtain an initial assessment of the capability of an early hit or lead compound to produce efficacious results (e.g., minimum efficacious dose (MED)) in vivo." @default.
- W1569013957 created "2016-06-24" @default.
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- W1569013957 date "2015-01-02" @default.
- W1569013957 modified "2023-09-23" @default.
- W1569013957 title "In VivoStudies of Brain Exposure in Drug Discovery" @default.
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- W1569013957 doi "https://doi.org/10.1002/9781118788523.ch13" @default.
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