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- W1569019154 abstract "The muscle-specific helix-loop-helix proteins MyoD and myogenin have been shown to positively autoregulate their own expression and to cross-activate one another's expression following transfection into a variety of nonmyogenic cell lines. We show that the ability of an exogenous myogenin expression vector to activate the endogenous myogenin allele in 10T1/2 fibroblasts is dependent on serum withdrawal. Repression of myogenin autoregulation by serum can be observed with a reporter gene linked to myogenin upstream sequences, indicating that repression occurs at the level of transcription. Like MyoD, myogenin exhibits a short half-life (approximately 20 min), which may serve to maintain the autoregulatory loop without allowing excess accumulation of the protein." @default.
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- W1569019154 date "1991-11-01" @default.
- W1569019154 modified "2023-09-30" @default.
- W1569019154 title "Mitogenic repression of myogenin autoregulation." @default.
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- W1569019154 doi "https://doi.org/10.1016/s0021-9258(18)54640-8" @default.
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