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- W1569031037 abstract "This chapter focuses on the analysis of nuclear receptor function in the mouse auditory system. Hearing is a prominent example of a sensory function that is regulated by nuclear receptors. Thyroid hormone receptors are essential for the development of hearing and other receptors. Although the requirement for a nuclear receptor gene may be suggested in some human inherited diseases with an incidence of hearing loss, the investigation of the underlying mechanisms requires a suitable model species. The mouse provides a valuable model because of the availability of spontaneous mutants and because it is amenable to genetic manipulation. Selected methods are presented in the chapter for studying the mouse auditory system, with a focus on the cochlea that contains the sensory hair cells. The cochlea within the inner ear houses a microcosm of cellular and physiological machinery that mediates auditory transduction. The overall function of the cochlea is highly dependent on its biomechanical structure. The easiest access to the cochlea is gained from the dorsal or upper surface of the base of the skull. Although increasing numbers of genes involved in cochlear function are being identified, the analysis of the regulation of these genes by nuclear receptors or other factors is still at an elementary stage." @default.
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- W1569031037 date "2003-01-01" @default.
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- W1569031037 title "Analysis of Nuclear Receptor Function in the Mouse Auditory System" @default.
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- W1569031037 doi "https://doi.org/10.1016/s0076-6879(03)64024-3" @default.
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