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- W156904248 abstract "The liver is the largest organ in the human body and has been used extensively as an important specimen in postmortem toxicology analysis. This chapter describes the advantages and disadvantages of using liver as a specimen for the detection and measurement of drugs-of-abuse in postmortem cases. The liver comprises relatively soft tissue amenable to the preparation of homogenates but contains high concentrations of lipids that may interfere in some analytical procedures. As a specimen, liver has the advantage that it is relatively unaffected by postmortem redistribution compared with blood, but drug concentrations in the lobe proximal to the stomach may be affected by postmortem diffusion in cases of oral overdose. The biggest impediment to the routine use of liver for the interpretation of positive drug findings is the lack of a comprehensive database of liver concentrations. The data contained here may assist those wishing to interpret liver concentrations of drugs-of-abuse. As for all drugs and specimens, the process of interpretation should include consideration of all aspects of the death investigation, including, as necessary, analysis of multiple specimens." @default.
- W156904248 created "2016-06-24" @default.
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- W156904248 date "2008-02-08" @default.
- W156904248 modified "2023-09-25" @default.
- W156904248 title "Drugs-of-Abuse in Liver" @default.
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- W156904248 doi "https://doi.org/10.1007/978-1-59745-318-9_9" @default.
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