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- W1569042912 abstract "We investigated the effect of paraoxon on vascular contractility using organ baths in thoracic aortic rings of rabbits and examined the effect of paraoxon on calcium homeostasis using a whole-cell patch-clamp technique in isolated aortic smooth muscle cells of rabbits. The findings show that administration of paraoxon (30 <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>μ</mml:mi><mml:mtext>M</mml:mtext></mml:mrow></mml:math>) attenuated thoracic aorta contraction induced by phenylephrine (1 <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>μ</mml:mi><mml:mtext>M</mml:mtext></mml:mrow></mml:math>) and/or a high<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:msup><mml:mtext>K</mml:mtext><mml:mo>+</mml:mo></mml:msup></mml:mrow></mml:math>environment (80 mM) in both the presence and absence of thoracic aortic endothelium. This inhibitory effect of paraoxon on vasoconstrictor-induced contraction was abolished in the absence of extracellular<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msup><mml:mtext>Ca</mml:mtext><mml:mrow><mml:mn>2</mml:mn><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:math>, or in the presence of the<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msup><mml:mtext>Ca</mml:mtext><mml:mrow><mml:mn>2</mml:mn><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:math>channel inhibitor, verapamil. But atropine had little effect on the inhibitory effect of paraoxon on phenylephrine-induced contraction. Paraoxon also attenuated vascular smooth muscle contraction induced by the cumulative addition of Ca<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:msub><mml:mrow><mml:mtext>Cl</mml:mtext></mml:mrow><mml:mn>2</mml:mn></mml:msub></mml:mrow></mml:math>and attenuated an increase of intracellular<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msup><mml:mtext>Ca</mml:mtext><mml:mrow><mml:mn>2</mml:mn><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:math>concentration induced by<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:msup><mml:mtext>K</mml:mtext><mml:mo>+</mml:mo></mml:msup></mml:mrow></mml:math>in vascular smooth muscle cells. Moreover, paraoxon (30 <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>μ</mml:mi><mml:mtext>M</mml:mtext></mml:mrow></mml:math>) inhibited significantly L-type calcium current in isolated aortic smooth muscle cells of rabbits. In conclusion, our results demonstrate that paraoxon attenuates vasoconstrictor-induced contraction through inhibiting<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msup><mml:mtext>Ca</mml:mtext><mml:mrow><mml:mn>2</mml:mn><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:math>influx in the rabbits thoracic aorta." @default.
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- W1569042912 date "2010-01-01" @default.
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- W1569042912 title "Paraoxon Attenuates Vascular Smooth Muscle Contraction through Inhibiting Ca2+Influx in the Rabbit Thoracic Aorta" @default.
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- W1569042912 doi "https://doi.org/10.1155/2010/829190" @default.
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