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- W1569058433 abstract "'Overall, this project is designed to identify the beryllium reactive T-cell clones that are proliferating in vivo in individuals sensitized to beryllium. The basic method for identifying such clones is the hprt T-cell mutation assay. The rationale is that in vivo proliferating T-lymphocytes are more likely to undergo hprt mutations and/or be included in hprt mutant fractions of T-cells isolated from peripheral blood. T-lymphocytes isolated as hprt mutants from beryllium sensitized individuals are propagated in vitro and characterized for T-cell receptor (TCR)/3 gene usage patterns and antigen reactivity. Results will be compared with similar characteristics determined for T-cell clones from the same individuals that were developed in vitro from peripheral blood lymphocytes by beryllium stimulation. This research project has several specific aims. Progress for the year 10/1/96 to 9/30/97 is given.'" @default.
- W1569058433 created "2016-06-24" @default.
- W1569058433 creator A5087766049 @default.
- W1569058433 date "1997-01-01" @default.
- W1569058433 modified "2023-10-14" @default.
- W1569058433 title "A novel biomarker for beryllium sensitization in humans. 1997 annual progress report" @default.
- W1569058433 doi "https://doi.org/10.2172/13585" @default.
- W1569058433 hasPublicationYear "1997" @default.
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