FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569059223> ?p ?o ?g. }

• W1569059223 abstract "Chronic hepatitis C is a leading cause of severe liver disease. Protease inhibitors used to treat these patients are known to have many drug interactions, although there is limited data available between boceprevir and warfarin. This case report is the first in vivo drug interaction reported in the literature. A 73-year-old African American man was diagnosed with hepatitis C in 2004, and had decided to not initiate therapy. In 2006, he was diagnosed with deep vein thrombosis and pulmonary embolism and was started on warfarin. His international normalized ratio had been stable on a dose of 13.75mg to 20mg/week over a period of 6 years. A liver biopsy in 2012 revealed marked fibrosis, leading the patient to start hepatitis C treatment with peginterferon alfa-2a, ribavirin and boceprevir. Three weeks after starting boceprevir, his international normalized ratio became subtherapeutic at 1.2. Upon increasing the warfarin dose by 16%, his international normalized ratio remained at 1.2 6 days later. Two months after initiating boceprevir, he reached a therapeutic international normalized ratio. His warfarin dose had been increased by 75% from his dose prior to starting boceprevir, from 15mg/week to 26.25mg/week. His hepatitis C treatment was discontinued at week 39 of the intended 48 weeks of treatment due to severe thrombocytopenia. Upon discontinuation of boceprevir, his warfarin dose was prophylactically decreased by 17%, which resulted in a subtherapeutic international normalized ratio of 1.48 1 week later. The warfarin dose was subsequently increased by 10% which resulted, 2 weeks later, in a therapeutic international normalized ratio of 2.8. Once stabilized, his new warfarin dose was 23.75mg/week, 37% higher than his original maintenance dose of 15mg/week prior to starting boceprevir. The co-administration of boceprevir and warfarin resulted in a subtherapeutic international normalized ratio. Upon starting boceprevir, his warfarin dose was increased by 75% over 2 months to achieve a therapeutic international normalized ratio. After discontinuing boceprevir, his maintenance dose of warfarin was 37% greater than his original dose. This is an original case report which demonstrates the significant effects of this drug interaction and the importance of monitoring international normalized ratio." @default.
• W1569059223 created "2016-06-24" @default.
• W1569059223 creator A5058349433 @default.
• W1569059223 creator A5070854902 @default.
• W1569059223 date "2014-12-01" @default.
• W1569059223 modified "2023-10-14" @default.
• W1569059223 title "Warfarin and boceprevir interaction causing subtherapeutic international normalized ratio: a case report" @default.
• W1569059223 cites W1605482820 @default.
• W1569059223 cites W1964401410 @default.
• W1569059223 cites W1970775695 @default.
• W1569059223 cites W1987665465 @default.
• W1569059223 cites W2024345076 @default.
• W1569059223 cites W2067978628 @default.
• W1569059223 cites W2073252808 @default.
• W1569059223 cites W2157961528 @default.
• W1569059223 cites W2168608777 @default.
• W1569059223 cites W2171070365 @default.
• W1569059223 doi "https://doi.org/10.1186/1752-1947-8-433" @default.
• W1569059223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4300681" @default.
• W1569059223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25515435" @default.
• W1569059223 hasPublicationYear "2014" @default.
• W1569059223 type Work @default.
• W1569059223 sameAs 1569059223 @default.
• W1569059223 citedByCount "4" @default.
• W1569059223 countsByYear W15690592232015 @default.
• W1569059223 countsByYear W15690592232016 @default.
• W1569059223 countsByYear W15690592232017 @default.
• W1569059223 countsByYear W15690592232019 @default.
• W1569059223 crossrefType "journal-article" @default.
• W1569059223 hasAuthorship W1569059223A5058349433 @default.
• W1569059223 hasAuthorship W1569059223A5070854902 @default.
• W1569059223 hasBestOaLocation W15690592231 @default.
• W1569059223 hasConcept C126322002 @default.
• W1569059223 hasConcept C159047783 @default.
• W1569059223 hasConcept C2522874641 @default.
• W1569059223 hasConcept C2776301958 @default.
• W1569059223 hasConcept C2776455275 @default.
• W1569059223 hasConcept C2777159539 @default.
• W1569059223 hasConcept C2778159067 @default.
• W1569059223 hasConcept C2779161974 @default.
• W1569059223 hasConcept C2780040827 @default.
• W1569059223 hasConcept C3020491458 @default.
• W1569059223 hasConcept C71924100 @default.
• W1569059223 hasConcept C90924648 @default.
• W1569059223 hasConceptScore W1569059223C126322002 @default.
• W1569059223 hasConceptScore W1569059223C159047783 @default.
• W1569059223 hasConceptScore W1569059223C2522874641 @default.
• W1569059223 hasConceptScore W1569059223C2776301958 @default.
• W1569059223 hasConceptScore W1569059223C2776455275 @default.
• W1569059223 hasConceptScore W1569059223C2777159539 @default.
• W1569059223 hasConceptScore W1569059223C2778159067 @default.
• W1569059223 hasConceptScore W1569059223C2779161974 @default.
• W1569059223 hasConceptScore W1569059223C2780040827 @default.
• W1569059223 hasConceptScore W1569059223C3020491458 @default.
• W1569059223 hasConceptScore W1569059223C71924100 @default.
• W1569059223 hasConceptScore W1569059223C90924648 @default.
• W1569059223 hasIssue "1" @default.
• W1569059223 hasLocation W15690592231 @default.
• W1569059223 hasLocation W15690592232 @default.
• W1569059223 hasLocation W15690592233 @default.
• W1569059223 hasLocation W15690592234 @default.
• W1569059223 hasOpenAccess W1569059223 @default.
• W1569059223 hasPrimaryLocation W15690592231 @default.
• W1569059223 hasRelatedWork W119403464 @default.
• W1569059223 hasRelatedWork W1574395574 @default.
• W1569059223 hasRelatedWork W1604648736 @default.
• W1569059223 hasRelatedWork W1939121468 @default.
• W1569059223 hasRelatedWork W1975576681 @default.
• W1569059223 hasRelatedWork W2048527229 @default.
• W1569059223 hasRelatedWork W2126620144 @default.
• W1569059223 hasRelatedWork W2130138040 @default.
• W1569059223 hasRelatedWork W2331002575 @default.
• W1569059223 hasRelatedWork W2977483558 @default.
• W1569059223 hasVolume "8" @default.
• W1569059223 isParatext "false" @default.
• W1569059223 isRetracted "false" @default.
• W1569059223 magId "1569059223" @default.
• W1569059223 workType "article" @default.