FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569061529> ?p ?o ?g. }

• W1569061529 endingPage "13301" @default.
• W1569061529 startingPage "13293" @default.
• W1569061529 abstract "The nuclear lamina, a structure closely apposed to the inner nuclear membrane, is believed to provide a framework important for nuclear envelope integrity and interphase chromatin organization. So far, in mammalian and avian species three major constituents of the lamina, lamins A, B, and C, have been identified. These proteins migrate to characteristic positions on two-dimensional gels, being more acidic than lamins A and C. Here, we show that the composition of the nuclear lamina in avian and mammalian cells is more complex than previously assumed. When analyzed on two-dimensional gels, the major 66-kDa chicken lamin B protein can readily be identified. However, an additional 68-kDa protein migrates to a similarly acidic position. Based on the following evidence, both proteins can be considered as two distinct members of the protein family. First, peptide mapping experiments and immunological criteria demonstrate that these two proteins are not related to each other or to A via postsynthetic modifications or precursor-product relationships. Second, as determined by immunocytochemical techniques, both proteins are located exclusively at the nuclear periphery. Third, both proteins display the biochemical properties characteristic of proteins, i.e. they are resistant to extraction of nuclei with nonionic detergents, nucleases, and high salt. Fourth, both proteins are immunologically related to previously characterized proteins: the major 66-kDa chicken lamin B protein shares at least two epitopes with A. However, contrary to what current nomenclature might suggest, this 66-kDa chicken lamin B protein is not related to rat liver B, but to a minor component of rat liver pore-complex lamina preparations that had not previously been recognized as a protein. Conversely, the minor 68-kDa component of chicken lamina preparations that had not previously been considered to be a protein is immunologically related to rat liver B. Thus, in addition to demonstrating the existence of quantitatively minor proteins in higher vertebrates, our results caution against assigning structural homologies between proteins from different species on the basis of gel electrophoresis analyses." @default.
• W1569061529 created "2016-06-24" @default.
• W1569061529 creator A5051447001 @default.
• W1569061529 creator A5063045608 @default.
• W1569061529 creator A5067286626 @default.
• W1569061529 creator A5086562799 @default.
• W1569061529 date "1986-10-01" @default.
• W1569061529 modified "2023-09-30" @default.
• W1569061529 title "The nuclear lamin protein family in higher vertebrates. Identification of quantitatively minor lamin proteins by monoclonal antibodies." @default.
• W1569061529 cites W14043844 @default.
• W1569061529 cites W1476434754 @default.
• W1569061529 cites W1497330482 @default.
• W1569061529 cites W1528696948 @default.
• W1569061529 cites W1530723120 @default.
• W1569061529 cites W1566845757 @default.
• W1569061529 cites W1568086666 @default.
• W1569061529 cites W1589365860 @default.
• W1569061529 cites W1602198467 @default.
• W1569061529 cites W1961878207 @default.
• W1569061529 cites W1969731560 @default.
• W1569061529 cites W1971122464 @default.
• W1569061529 cites W1979492674 @default.
• W1569061529 cites W1979725861 @default.
• W1569061529 cites W1985209758 @default.
• W1569061529 cites W1988510960 @default.
• W1569061529 cites W1989800269 @default.
• W1569061529 cites W1992976978 @default.
• W1569061529 cites W1994304154 @default.
• W1569061529 cites W1994748744 @default.
• W1569061529 cites W1996451278 @default.
• W1569061529 cites W2000982290 @default.
• W1569061529 cites W2005063559 @default.
• W1569061529 cites W2008634878 @default.
• W1569061529 cites W2008900071 @default.
• W1569061529 cites W2012550276 @default.
• W1569061529 cites W2013661745 @default.
• W1569061529 cites W2020538144 @default.
• W1569061529 cites W2021783076 @default.
• W1569061529 cites W2023626995 @default.
• W1569061529 cites W2030415964 @default.
• W1569061529 cites W2031725750 @default.
• W1569061529 cites W2032984278 @default.
• W1569061529 cites W2034277598 @default.
• W1569061529 cites W2040118862 @default.
• W1569061529 cites W2041762028 @default.
• W1569061529 cites W2045204280 @default.
• W1569061529 cites W2047178493 @default.
• W1569061529 cites W2047928048 @default.
• W1569061529 cites W2049351973 @default.
• W1569061529 cites W2052095497 @default.
• W1569061529 cites W2053999422 @default.
• W1569061529 cites W2064264835 @default.
• W1569061529 cites W2066526604 @default.
• W1569061529 cites W2071515942 @default.
• W1569061529 cites W2072245143 @default.
• W1569061529 cites W2077423941 @default.
• W1569061529 cites W2083453910 @default.
• W1569061529 cites W2087176490 @default.
• W1569061529 cites W2100837269 @default.
• W1569061529 cites W2139813093 @default.
• W1569061529 cites W2149467639 @default.
• W1569061529 cites W2162929205 @default.
• W1569061529 cites W2210841215 @default.
• W1569061529 cites W2314091134 @default.
• W1569061529 cites W2395372445 @default.
• W1569061529 cites W2404350895 @default.
• W1569061529 cites W31188398 @default.
• W1569061529 doi "https://doi.org/10.1016/s0021-9258(18)69303-2" @default.
• W1569061529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3531199" @default.
• W1569061529 hasPublicationYear "1986" @default.
• W1569061529 type Work @default.
• W1569061529 sameAs 1569061529 @default.
• W1569061529 citedByCount "125" @default.
• W1569061529 countsByYear W15690615292013 @default.
• W1569061529 countsByYear W15690615292016 @default.
• W1569061529 countsByYear W15690615292017 @default.
• W1569061529 countsByYear W15690615292018 @default.
• W1569061529 crossrefType "journal-article" @default.
• W1569061529 hasAuthorship W1569061529A5051447001 @default.
• W1569061529 hasAuthorship W1569061529A5063045608 @default.
• W1569061529 hasAuthorship W1569061529A5067286626 @default.
• W1569061529 hasAuthorship W1569061529A5086562799 @default.
• W1569061529 hasBestOaLocation W15690615291 @default.
• W1569061529 hasConcept C104317684 @default.
• W1569061529 hasConcept C116834253 @default.
• W1569061529 hasConcept C153911025 @default.
• W1569061529 hasConcept C159654299 @default.
• W1569061529 hasConcept C179093185 @default.
• W1569061529 hasConcept C542903549 @default.
• W1569061529 hasConcept C54355233 @default.
• W1569061529 hasConcept C59822182 @default.
• W1569061529 hasConcept C86803240 @default.
• W1569061529 hasConceptScore W1569061529C104317684 @default.
• W1569061529 hasConceptScore W1569061529C116834253 @default.
• W1569061529 hasConceptScore W1569061529C153911025 @default.
• W1569061529 hasConceptScore W1569061529C159654299 @default.
• W1569061529 hasConceptScore W1569061529C179093185 @default.
• W1569061529 hasConceptScore W1569061529C542903549 @default.

• next