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- W1569071345 abstract "The following pages are the result of a study of cases of very early and actually beginning carcinomata of the skin. In an earlier paper (1), I discussed in some detail von Hansemann9s theory of anaplasia, and tried to indicate how naturally and easily that theory develops, in the light of present knowledge of the laws of inheritance, into one which regards the cancer cell as a product of somatic mutation. So simple and direct, indeed, is that development, that the difference is largely the difference between the terminology of thirty years ago and that of today. It follows of course that the present point of view contains little that is new. The anaplastic cell of von Hansemann becomes quite naturally the new race of cells of Hauser; so that I am by no means the first to apply either the concept or the term, mutation, to cancer genesis. But the application to the problem of the remarkable observations of Morgan and his associates gave me, I felt, such added understanding that it seemed worth while publishing it. The present paper attempts to approach the problem from the same viewpoint as the earlier one but to present it in a more objective, less abstract form. Since it is largely based on the same bibliography as the preceding paper, it has seemed unnecessary to repeat that given there. The present study embraces seven cases about equally divided between the cornifying and the non-cornifying types. The non-cornifying tumors will be discussed under a distinctive title. Ribbert (2) bases the distinction between the two forms on the mode of growth." @default.
- W1569071345 created "2016-06-24" @default.
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- W1569071345 date "1920-04-01" @default.
- W1569071345 modified "2023-09-23" @default.
- W1569071345 title "A Study of Four Cases of Beginning Squamouscell Carcinoma of Cornifying Type" @default.
- W1569071345 doi "https://doi.org/10.1158/jcr.1920.155" @default.
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