Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569073402> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W1569073402 endingPage "15" @default.
- W1569073402 startingPage "707" @default.
- W1569073402 abstract "At the time of diagnosis, central nervous system (CNS) involvement is identified in less than 10% of adult acute lymphoblastic leukemia (ALL). Long-term disease-free survival can be achieved in these patients. CNS disease at presentation does not appear to be an independent poor prognostic factor. In CNS leukemia, innovative treatments and alternative delivery techniques are, however, warranted. Outcome in such patients is a reflection of an aggressive systemic and CNS-directed therapy. However, CNS toxicity represents the dose-limiting side effect of treatment. With effective CNS prophylaxis including intrathecal chemotherapy, high-dose systemic administration of certain agents and cranial irradiation, most adults with ALL without CNS disease at diagnosis may remain free of CNS leukemia. CNS involvement at the time of relapse occurs in 1 to 15% of cases. Leukemic relapse remains a major therapeutic challenge. Adult ALL with CNS recurrence remains of poor prognosis and is generally associated with a systemic and medullary relapse." @default.
- W1569073402 created "2016-06-24" @default.
- W1569073402 creator A5019076398 @default.
- W1569073402 creator A5072721892 @default.
- W1569073402 creator A5087870886 @default.
- W1569073402 date "2008-08-30" @default.
- W1569073402 modified "2023-10-14" @default.
- W1569073402 title "[Adult acute lymphoblastic leukemia with central nervous system involvement: an overview]." @default.
- W1569073402 doi "https://doi.org/10.1684/bdc.2008.0645" @default.
- W1569073402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18755650" @default.
- W1569073402 hasPublicationYear "2008" @default.
- W1569073402 type Work @default.
- W1569073402 sameAs 1569073402 @default.
- W1569073402 citedByCount "1" @default.
- W1569073402 countsByYear W15690734022012 @default.
- W1569073402 crossrefType "journal-article" @default.
- W1569073402 hasAuthorship W1569073402A5019076398 @default.
- W1569073402 hasAuthorship W1569073402A5072721892 @default.
- W1569073402 hasAuthorship W1569073402A5087870886 @default.
- W1569073402 hasConcept C126322002 @default.
- W1569073402 hasConcept C143998085 @default.
- W1569073402 hasConcept C203014093 @default.
- W1569073402 hasConcept C2776694085 @default.
- W1569073402 hasConcept C2778461978 @default.
- W1569073402 hasConcept C2779134260 @default.
- W1569073402 hasConcept C2781107101 @default.
- W1569073402 hasConcept C2909962599 @default.
- W1569073402 hasConcept C529278444 @default.
- W1569073402 hasConcept C71924100 @default.
- W1569073402 hasConceptScore W1569073402C126322002 @default.
- W1569073402 hasConceptScore W1569073402C143998085 @default.
- W1569073402 hasConceptScore W1569073402C203014093 @default.
- W1569073402 hasConceptScore W1569073402C2776694085 @default.
- W1569073402 hasConceptScore W1569073402C2778461978 @default.
- W1569073402 hasConceptScore W1569073402C2779134260 @default.
- W1569073402 hasConceptScore W1569073402C2781107101 @default.
- W1569073402 hasConceptScore W1569073402C2909962599 @default.
- W1569073402 hasConceptScore W1569073402C529278444 @default.
- W1569073402 hasConceptScore W1569073402C71924100 @default.
- W1569073402 hasIssue "7" @default.
- W1569073402 hasLocation W15690734021 @default.
- W1569073402 hasOpenAccess W1569073402 @default.
- W1569073402 hasPrimaryLocation W15690734021 @default.
- W1569073402 hasRelatedWork W1964084982 @default.
- W1569073402 hasRelatedWork W197209903 @default.
- W1569073402 hasRelatedWork W1995529445 @default.
- W1569073402 hasRelatedWork W2001323814 @default.
- W1569073402 hasRelatedWork W2026713120 @default.
- W1569073402 hasRelatedWork W2029897923 @default.
- W1569073402 hasRelatedWork W2030632445 @default.
- W1569073402 hasRelatedWork W2067420012 @default.
- W1569073402 hasRelatedWork W2070244791 @default.
- W1569073402 hasRelatedWork W2114032004 @default.
- W1569073402 hasRelatedWork W2122179779 @default.
- W1569073402 hasRelatedWork W2165778392 @default.
- W1569073402 hasRelatedWork W2187695891 @default.
- W1569073402 hasRelatedWork W2372208449 @default.
- W1569073402 hasRelatedWork W2407746943 @default.
- W1569073402 hasRelatedWork W2410519085 @default.
- W1569073402 hasRelatedWork W2417919348 @default.
- W1569073402 hasRelatedWork W361951014 @default.
- W1569073402 hasRelatedWork W7217595 @default.
- W1569073402 hasRelatedWork W90015532 @default.
- W1569073402 hasVolume "95" @default.
- W1569073402 isParatext "false" @default.
- W1569073402 isRetracted "false" @default.
- W1569073402 magId "1569073402" @default.
- W1569073402 workType "article" @default.