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• W1569074827 abstract "Article1 July 1940STUDIES IN THE METABOLISM OF DEXTROSE FRAGMENTS IN MANFRANCES F. BECK, PH.D., RUTH MUSSER, M.S., C. JELLEFF CARR, PH.D., JOHN C. KRANTZ JR., PH.D.FRANCES F. BECK, PH.D.Search for more papers by this author, RUTH MUSSER, M.S.Search for more papers by this author, C. JELLEFF CARR, PH.D.Search for more papers by this author, JOHN C. KRANTZ JR., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-1-122 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe problem of producing a substitute carbohydrate for dextrose in the treatment of diabetes has been studied extensively by various investigators. This subject was comprehensively reviewed by Gottschalk1in 1929. Not any of the compounds studied has proved satisfactory from the point of view of being metabolized with a smaller amount of insulin than is dextrose. Moreover these compounds have defects as to availability, toxicity and taste. Perhaps the most promising substance studied for this purpose was dihydroxyacetone, investigated by Rabinowitch.2The possible merits of this substance at present, at least, are off-set by the cost of manufacture and...Bibliography1. GOTTSCHALK A: The importance of substitute carbohydrate for the practice and theory of diabetes mellitus, Ergebn. d. inn. Med. u. Kinderh., 1929, xxxvi, 56. Google Scholar2. RABINOWITCH IM: Observations on the use of dihydroxyacetone in the treatment of diabetes mellitus, Canad. Med. Assoc. Jr., 1925, xv, 374. Google Scholar3. NEF JU: Dissoziationsvorgänge in der Zuckergruppe, Ann. d. Chem., 1907, ccclvii, 214. CrossrefGoogle Scholar4. FISCHLER F: Beiträge zur Frage der Zuckerwirkung im Organisms. I. Mitteilung. Über Zuckerspaltung unter der Wirkung stark verdünnten Alkalis, Ztschr. f. physiol. Chem., 1926, clvii. Google Scholar5. NEF JU: Dissoziationsvorgänge in der Zuckergruppe, Ann. d. Chem., 1914, cd, 364. Google Scholar6. KRANTZMUSSERCARR JCRJC: Studies in the metabolism of alkalinized dextrose, Arch. Internat. de Pharmacodyn. et de thérap., 1937, lv, 9. Google Scholar7. KRANTZCARR JCCJ: A statistical study of the metabolism of the fasting albino rat, Jr. Nutr., 1935, ix, 363. CrossrefGoogle Scholar8. FOLIN O: A new blood sugar method, Jr. Biol. Chem., 1928, lxxvii, 421. CrossrefGoogle Scholar9. KERMACK WO: Studies in carbohydrate metabolism. I. The utilization of dihydroxyacetone in the animal body and a method for its estimation, Biochem. Jr., 1926, xx, 486. CrossrefGoogle Scholar10. RINGERFRANKEL AIEM: The chemistry of gluconeogenesis. IX. The formation of glucose from dihydroxyacetone in the diabetic organism, Jr. Biol. Chem., 1914, xviii, 233. CrossrefGoogle Scholar11. GREVENSTUKLAQUER : Insulin, Bergmann, München, 1925. Through MACLEOD, J. J. R.: Carbohydrate metabolism and insulin, 1926, Longmans, Green and Co., London. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication June 3, 1938.From the Department of Pharmacology, School of Medicine, University of Maryland.The authors wish to acknowledge their indebtedness to the Department of Medicine of this School for their coöperation in supplying diabetic subjects for this test.The expense of this investigation was defrayed in part by a grant from the Committee on Therapeutic Research of the Council of Pharmacy and Chemistry of the American Medical Association. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHistory of the synthesis and pharmacology of isosorbide dinitrate 1 July 1940Volume 14, Issue 1Page: 122-128KeywordsCarbohydratesGlucoseInsulinPharmacologyTasteToxicity ePublished: 1 December 2008 Issue Published: 1 July 1940 PDF downloadLoading ..." @default.
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