FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569083792> ?p ?o ?g. }

• W1569083792 endingPage "4079" @default.
• W1569083792 startingPage "4072" @default.
• W1569083792 abstract "The acute-phase proteins, C-reactive protein and serum amyloid A (SAA), are biomarkers of infection and inflammation. However, their precise role in immunity and inflammation remains undefined. We report in this study a novel property of SAA in the differential induction of Th1-type immunomodulatory cytokines IL-12 and IL-23. In peripheral blood monocytes and the THP-1 monocytic cell line, SAA induces the expression of IL-12p40, a subunit shared by IL-12 and IL-23. SAA-stimulated expression of IL-12p40 was rapid (< or = 4 h), sustainable (> or = 20 h), potent (up to 3380 pg/ml/10(6) cells in 24 h), and insensitive to polymyxin B treatment. The SAA-stimulated IL-12p40 secretion required de novo protein synthesis and was accompanied by activation of the transcription factors NF-kappaB and C/EBP. Expression of IL-12p40 required activation of the p38 MAPK and PI3K. Interestingly, the SAA-induced IL-12p40 production was accompanied by a sustained expression of IL-23p19, but not IL-12p35, resulting in preferential secretion of IL-23, but not IL-12. These results identify SAA as an endogenous ligand that potentially activates the IL-23/IL-17 pathway and present a novel mechanism for regulation of inflammation and immunity by an acute-phase protein." @default.
• W1569083792 created "2016-06-24" @default.
• W1569083792 creator A5016734479 @default.
• W1569083792 creator A5051992203 @default.
• W1569083792 creator A5061130250 @default.
• W1569083792 creator A5066886337 @default.
• W1569083792 creator A5079731167 @default.
• W1569083792 date "2006-09-15" @default.
• W1569083792 modified "2023-10-08" @default.
• W1569083792 title "Serum Amyloid A Is an Endogenous Ligand That Differentially Induces IL-12 and IL-23" @default.
• W1569083792 cites W1487900963 @default.
• W1569083792 cites W1501713285 @default.
• W1569083792 cites W1575242432 @default.
• W1569083792 cites W1598647759 @default.
• W1569083792 cites W1857206577 @default.
• W1569083792 cites W1966999437 @default.
• W1569083792 cites W1970546329 @default.
• W1569083792 cites W1976775782 @default.
• W1569083792 cites W1980547319 @default.
• W1569083792 cites W1991464867 @default.
• W1569083792 cites W1993243592 @default.
• W1569083792 cites W2000011436 @default.
• W1569083792 cites W2006178861 @default.
• W1569083792 cites W2006249161 @default.
• W1569083792 cites W2013675404 @default.
• W1569083792 cites W2016210580 @default.
• W1569083792 cites W2021786991 @default.
• W1569083792 cites W2029108630 @default.
• W1569083792 cites W2037512627 @default.
• W1569083792 cites W2038165778 @default.
• W1569083792 cites W2040542504 @default.
• W1569083792 cites W2043409894 @default.
• W1569083792 cites W2044490327 @default.
• W1569083792 cites W2045309329 @default.
• W1569083792 cites W2048521619 @default.
• W1569083792 cites W2057017180 @default.
• W1569083792 cites W2058156668 @default.
• W1569083792 cites W2065123578 @default.
• W1569083792 cites W2070619903 @default.
• W1569083792 cites W2072113749 @default.
• W1569083792 cites W2076889715 @default.
• W1569083792 cites W2080503511 @default.
• W1569083792 cites W2085904775 @default.
• W1569083792 cites W2090197666 @default.
• W1569083792 cites W2092902948 @default.
• W1569083792 cites W2098586771 @default.
• W1569083792 cites W2103602099 @default.
• W1569083792 cites W2104439753 @default.
• W1569083792 cites W2108487670 @default.
• W1569083792 cites W2114492564 @default.
• W1569083792 cites W2116828514 @default.
• W1569083792 cites W2123116789 @default.
• W1569083792 cites W2123960592 @default.
• W1569083792 cites W2124051584 @default.
• W1569083792 cites W2126736180 @default.
• W1569083792 cites W2127704524 @default.
• W1569083792 cites W2130688895 @default.
• W1569083792 cites W2130888600 @default.
• W1569083792 cites W2130933356 @default.
• W1569083792 cites W2132342511 @default.
• W1569083792 cites W2139731518 @default.
• W1569083792 cites W2154746915 @default.
• W1569083792 cites W2158854771 @default.
• W1569083792 cites W2159406914 @default.
• W1569083792 cites W2159546356 @default.
• W1569083792 cites W2160746910 @default.
• W1569083792 cites W2167362639 @default.
• W1569083792 cites W2170966854 @default.
• W1569083792 cites W2170992520 @default.
• W1569083792 cites W2279245773 @default.
• W1569083792 cites W2317184793 @default.
• W1569083792 cites W2324640604 @default.
• W1569083792 cites W2538197248 @default.
• W1569083792 doi "https://doi.org/10.4049/jimmunol.177.6.4072" @default.
• W1569083792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16951371" @default.
• W1569083792 hasPublicationYear "2006" @default.
• W1569083792 type Work @default.
• W1569083792 sameAs 1569083792 @default.
• W1569083792 citedByCount "88" @default.
• W1569083792 countsByYear W15690837922012 @default.
• W1569083792 countsByYear W15690837922013 @default.
• W1569083792 countsByYear W15690837922014 @default.
• W1569083792 countsByYear W15690837922015 @default.
• W1569083792 countsByYear W15690837922016 @default.
• W1569083792 countsByYear W15690837922017 @default.
• W1569083792 countsByYear W15690837922018 @default.
• W1569083792 countsByYear W15690837922019 @default.
• W1569083792 countsByYear W15690837922020 @default.
• W1569083792 countsByYear W15690837922021 @default.
• W1569083792 countsByYear W15690837922022 @default.
• W1569083792 countsByYear W15690837922023 @default.
• W1569083792 crossrefType "journal-article" @default.
• W1569083792 hasAuthorship W1569083792A5016734479 @default.
• W1569083792 hasAuthorship W1569083792A5051992203 @default.
• W1569083792 hasAuthorship W1569083792A5061130250 @default.
• W1569083792 hasAuthorship W1569083792A5066886337 @default.
• W1569083792 hasAuthorship W1569083792A5079731167 @default.
• W1569083792 hasBestOaLocation W15690837921 @default.

• next