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- W1569085863 abstract "Abstract Comparison of ultrastructural and biochemical response to adrenocorticotropic hormone (ACTH) in superfused adrenals or cell suspension and in adrenals of hypophysectomized rats showed that (a) steroidogenic response can take place in superfused glands that have suffered gross structural damage and contained no detectable intact mitochondria; (b) steroidogenesis of cell suspensions takes place without dilation of the endoplasmic reticulum; (c) adrenals of 1-day posthypophysectomized rats respond normally to ACTH in terms of ultrastructural changes even though they have lost their responsiveness to ACTH in terms of steroidogenesis; (d) these ACTH-induced ultrastructural changes in adrenals of hypophysectomized rats are blocked by the prior administration of cycloheximide and postulated to be dependent upon the translation of preformed mRNA with a longer half-life than the mRNA coding for the labile steroidogenic protein." @default.
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- W1569085863 date "1973-10-01" @default.
- W1569085863 modified "2023-09-30" @default.
- W1569085863 title "Comparison of the Effects of Adrenocorticotropic Hormone on the Steroidogenic Activity and Ultrastructure of Adrenal Cortex" @default.
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- W1569085863 doi "https://doi.org/10.1016/s0021-9258(19)43406-6" @default.
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