Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569086356> ?p ?o ?g. }
- W1569086356 abstract "The ability of brain-derived neurotrophic factor (BDNF) to attenuate secondary damage and influence behavioral outcome after experimental traumatic brain injury (TBI) remains controversial. Because TBI can result in decreased expression of the trkB receptor, thereby preventing BDNF from exerting potential neuroprotective effects, the contribution of both BDNF and its receptor trkB to hippocampal neuronal loss and cognitive dysfunction were evaluated.Full-length trkB was overexpressed in the left hippocampus of adult C57Bl/6 mice using recombinant adeno-associated virus serotype 2/5 (rAAV 2/5). EGFP (enhanced green fluorescent protein) expression was present at two weeks after AAV-EGFP injection and remained sustained up to four weeks after the injection. At 2 weeks following gene transduction, mice were subjected to parasagittal controlled cortical impact (CCI) brain injury, followed by either BDNF or PBS infusion into the hippocampus.No differences were observed in learning ability at two weeks post-injury or in motor function from 48 hours to two weeks among treatment groups. The number of surviving pyramidal neurons in the CA2-CA3 region of the hippocampus was also not different among treatment groups.These data suggest that neither overexpression of trkB, BNDF infusion or their combination affects neuronal survival or behavioral outcome following experimental TBI in mice." @default.
- W1569086356 created "2016-06-24" @default.
- W1569086356 creator A5009788180 @default.
- W1569086356 creator A5010152737 @default.
- W1569086356 creator A5038221757 @default.
- W1569086356 creator A5044253043 @default.
- W1569086356 creator A5046564023 @default.
- W1569086356 creator A5061860555 @default.
- W1569086356 creator A5077816873 @default.
- W1569086356 creator A5057986203 @default.
- W1569086356 date "2008-01-01" @default.
- W1569086356 modified "2023-09-23" @default.
- W1569086356 title "TrkB gene transfer does not alter hippocampal neuronal loss and cognitive deficits following traumatic brain injury in mice." @default.
- W1569086356 cites W1561325891 @default.
- W1569086356 cites W1565095682 @default.
- W1569086356 cites W1575167357 @default.
- W1569086356 cites W1591302719 @default.
- W1569086356 cites W1601499949 @default.
- W1569086356 cites W1677823991 @default.
- W1569086356 cites W1747922801 @default.
- W1569086356 cites W1813945002 @default.
- W1569086356 cites W1868514048 @default.
- W1569086356 cites W1973211319 @default.
- W1569086356 cites W1975823509 @default.
- W1569086356 cites W1977232716 @default.
- W1569086356 cites W1977358187 @default.
- W1569086356 cites W1979899463 @default.
- W1569086356 cites W1980280927 @default.
- W1569086356 cites W1983490728 @default.
- W1569086356 cites W1985815419 @default.
- W1569086356 cites W1986538583 @default.
- W1569086356 cites W1988660081 @default.
- W1569086356 cites W1999335813 @default.
- W1569086356 cites W2004273706 @default.
- W1569086356 cites W2004469687 @default.
- W1569086356 cites W2004670058 @default.
- W1569086356 cites W2006759122 @default.
- W1569086356 cites W2012674530 @default.
- W1569086356 cites W2016191408 @default.
- W1569086356 cites W2018465654 @default.
- W1569086356 cites W2020843119 @default.
- W1569086356 cites W2023715580 @default.
- W1569086356 cites W2027105684 @default.
- W1569086356 cites W2027588570 @default.
- W1569086356 cites W2030938312 @default.
- W1569086356 cites W2033333756 @default.
- W1569086356 cites W2033557808 @default.
- W1569086356 cites W2034135331 @default.
- W1569086356 cites W2040786733 @default.
- W1569086356 cites W2041171950 @default.
- W1569086356 cites W2044712342 @default.
- W1569086356 cites W2047075116 @default.
- W1569086356 cites W2047144068 @default.
- W1569086356 cites W2050451007 @default.
- W1569086356 cites W2050892749 @default.
- W1569086356 cites W2054213981 @default.
- W1569086356 cites W2056398740 @default.
- W1569086356 cites W2063964698 @default.
- W1569086356 cites W2067629356 @default.
- W1569086356 cites W2069462123 @default.
- W1569086356 cites W2071450780 @default.
- W1569086356 cites W2073539399 @default.
- W1569086356 cites W2080426752 @default.
- W1569086356 cites W2087975086 @default.
- W1569086356 cites W2091316910 @default.
- W1569086356 cites W2091758977 @default.
- W1569086356 cites W2092324476 @default.
- W1569086356 cites W2110575642 @default.
- W1569086356 cites W2110795584 @default.
- W1569086356 cites W2111405228 @default.
- W1569086356 cites W2122906925 @default.
- W1569086356 cites W2139565721 @default.
- W1569086356 cites W2188166394 @default.
- W1569086356 cites W2222580064 @default.
- W1569086356 cites W2352727163 @default.
- W1569086356 cites W3148685111 @default.
- W1569086356 cites W43432051 @default.
- W1569086356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2580053" @default.
- W1569086356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18431005" @default.
- W1569086356 hasPublicationYear "2008" @default.
- W1569086356 type Work @default.
- W1569086356 sameAs 1569086356 @default.
- W1569086356 citedByCount "11" @default.
- W1569086356 countsByYear W15690863562012 @default.
- W1569086356 countsByYear W15690863562015 @default.
- W1569086356 countsByYear W15690863562017 @default.
- W1569086356 countsByYear W15690863562020 @default.
- W1569086356 countsByYear W15690863562023 @default.
- W1569086356 crossrefType "journal-article" @default.
- W1569086356 hasAuthorship W1569086356A5009788180 @default.
- W1569086356 hasAuthorship W1569086356A5010152737 @default.
- W1569086356 hasAuthorship W1569086356A5038221757 @default.
- W1569086356 hasAuthorship W1569086356A5044253043 @default.
- W1569086356 hasAuthorship W1569086356A5046564023 @default.
- W1569086356 hasAuthorship W1569086356A5057986203 @default.
- W1569086356 hasAuthorship W1569086356A5061860555 @default.
- W1569086356 hasAuthorship W1569086356A5077816873 @default.
- W1569086356 hasConcept C118552586 @default.
- W1569086356 hasConcept C126322002 @default.
- W1569086356 hasConcept C134018914 @default.