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- W1569088201 abstract "Chronic obstructive pulmonary disease (COPD) is a progressive, debilitating disorder that results in frequent exacerbations and impacts quality of life. It represents a growing burden of health care cost, both from societal and economic perspectives. Short- and long-acting bronchodilators remain the mainstay of therapy in COPD patients. New fixed-dose combination inhalers with novel pharmacological combinations of long-acting β2-agonists and muscarinic antagonists and delivered once-daily through a variety of devices are currently being developed and licensed for the treatment of COPD. There is mounting research suggesting that combining a fixed dose of a β2-agonist and a muscarinic antagonist achieves better bronchodilation and clinical outcomes compared with either agent alone. These once-daily dosing inhalers are anticipated to impact favorably on patient preference and compliance. This review examines the fixed-dose combination of tiotropium bromide and olodaterol delivered by a Respimat(®) Soft Mist™ inhaler at doses of 2.5/5 μg and 5/5 μg in moderate-to-very-severe COPD, and its potential role in COPD compared with other long-acting β2-agonist with long-acting muscarinic antagonist combinations and delivery devices." @default.
- W1569088201 created "2016-06-24" @default.
- W1569088201 creator A5020443919 @default.
- W1569088201 creator A5055927650 @default.
- W1569088201 date "2015-06-01" @default.
- W1569088201 modified "2023-09-23" @default.
- W1569088201 title "Profile of a fixed-dose combination of tiotropium/olodaterol and its potential in the treatment of COPD" @default.
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- W1569088201 doi "https://doi.org/10.2147/copd.s54154" @default.
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