FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569090774> ?p ?o ?g. }

• W1569090774 endingPage "2932" @default.
• W1569090774 startingPage "2925" @default.
• W1569090774 abstract "K+ is required for the stimulation by the antibiotic nigericin of adenosine triphosphate hydrolysis in rat liver mitochondria. This action does not occur when K+ is replaced by other monovalent cations. It requires slightly hypotonic conditions and is not related to the swelling phenomena linked to the accumulation of K+ in mitochondria. ATPase is inhibited by small anion molecules to which the mitochondrial membrane is impermeable, less so if the anion is translocated inside the mitochondria. High concentrations of Rb+ or Na+ and low concentrations of Ca++ inhibit the ATPase stimulated by nigericin. The ATPase activity of submitochondrial sonic fragments, and of Racker's coupling factor F1, are not stimulated by nigericin. β-Hydroxybutyrate and succinate partially inhibit the hydrolysis of ATP stimulated by nigericin in K+ media. Neither glutamate, malate, pyruvate, nor α-ketoglutarate inhibits this enzymatic activity. The inhibition of ATPase by oxidizable substrates is ascribed to the reincorporation of the liberated inorganic orthophosphate into ADP by way of the phosphorylation linked to the oxidation of succinate and β-hydroxybutyrate. Low concentrations of nigericin partially inhibit the ATPase stimulated by uncoupling agents requiring the presence of alkali metal cations for their mechanism of action; the inhibition depends on the ionic environment of the mitochondria. Nigericin does not affect ATPase activities induced by agents with no alkali metal cation requirement. Dianemycin, an antibiotic with properties similar to nigericin regarding induced ion movement and spectra of respiratory inhibition, does not stimulate the hydrolysis of ATP in any of several media tried. The K+-dependent ATPase stimulated by nigericin appears not to be related to a translocation of alkali metal cations induced by the antibiotic. The possibility that the induction of this activity is related to the participation of a potassium-dependent step in the sequence of reactions leading to the synthesis of ATP in mitochondria is discussed." @default.
• W1569090774 created "2016-06-24" @default.
• W1569090774 creator A5024786763 @default.
• W1569090774 creator A5049241852 @default.
• W1569090774 creator A5050908360 @default.
• W1569090774 date "1967-06-01" @default.
• W1569090774 modified "2023-09-30" @default.
• W1569090774 title "Potassium Ion-dependent Hydrolysis of Adenosine Triphosphate Induced by Nigericin in Mitochondria" @default.
• W1569090774 cites W119802141 @default.
• W1569090774 cites W1550542945 @default.
• W1569090774 cites W155146360 @default.
• W1569090774 cites W1578981664 @default.
• W1569090774 cites W184269407 @default.
• W1569090774 cites W186485332 @default.
• W1569090774 cites W1963677960 @default.
• W1569090774 cites W1964086170 @default.
• W1569090774 cites W1969338482 @default.
• W1569090774 cites W1981217589 @default.
• W1569090774 cites W1984014773 @default.
• W1569090774 cites W1985372678 @default.
• W1569090774 cites W1986624219 @default.
• W1569090774 cites W2015673502 @default.
• W1569090774 cites W2021241222 @default.
• W1569090774 cites W2032895709 @default.
• W1569090774 cites W2037968674 @default.
• W1569090774 cites W2045110236 @default.
• W1569090774 cites W2049798941 @default.
• W1569090774 cites W2051429945 @default.
• W1569090774 cites W2085601460 @default.
• W1569090774 cites W2086150823 @default.
• W1569090774 cites W2088216903 @default.
• W1569090774 cites W2090037772 @default.
• W1569090774 cites W2344532313 @default.
• W1569090774 cites W2415440234 @default.
• W1569090774 cites W62397613 @default.
• W1569090774 doi "https://doi.org/10.1016/s0021-9258(18)99593-1" @default.
• W1569090774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4226121" @default.
• W1569090774 hasPublicationYear "1967" @default.
• W1569090774 type Work @default.
• W1569090774 sameAs 1569090774 @default.
• W1569090774 citedByCount "35" @default.
• W1569090774 countsByYear W15690907742023 @default.
• W1569090774 crossrefType "journal-article" @default.
• W1569090774 hasAuthorship W1569090774A5024786763 @default.
• W1569090774 hasAuthorship W1569090774A5049241852 @default.
• W1569090774 hasAuthorship W1569090774A5050908360 @default.
• W1569090774 hasBestOaLocation W15690907741 @default.
• W1569090774 hasConcept C12554922 @default.
• W1569090774 hasConcept C141315368 @default.
• W1569090774 hasConcept C145148216 @default.
• W1569090774 hasConcept C178790620 @default.
• W1569090774 hasConcept C181199279 @default.
• W1569090774 hasConcept C185592680 @default.
• W1569090774 hasConcept C23265538 @default.
• W1569090774 hasConcept C2776991684 @default.
• W1569090774 hasConcept C2777330628 @default.
• W1569090774 hasConcept C2779564974 @default.
• W1569090774 hasConcept C28859421 @default.
• W1569090774 hasConcept C41625074 @default.
• W1569090774 hasConcept C517785266 @default.
• W1569090774 hasConcept C55493867 @default.
• W1569090774 hasConcept C86803240 @default.
• W1569090774 hasConcept C94412978 @default.
• W1569090774 hasConceptScore W1569090774C12554922 @default.
• W1569090774 hasConceptScore W1569090774C141315368 @default.
• W1569090774 hasConceptScore W1569090774C145148216 @default.
• W1569090774 hasConceptScore W1569090774C178790620 @default.
• W1569090774 hasConceptScore W1569090774C181199279 @default.
• W1569090774 hasConceptScore W1569090774C185592680 @default.
• W1569090774 hasConceptScore W1569090774C23265538 @default.
• W1569090774 hasConceptScore W1569090774C2776991684 @default.
• W1569090774 hasConceptScore W1569090774C2777330628 @default.
• W1569090774 hasConceptScore W1569090774C2779564974 @default.
• W1569090774 hasConceptScore W1569090774C28859421 @default.
• W1569090774 hasConceptScore W1569090774C41625074 @default.
• W1569090774 hasConceptScore W1569090774C517785266 @default.
• W1569090774 hasConceptScore W1569090774C55493867 @default.
• W1569090774 hasConceptScore W1569090774C86803240 @default.
• W1569090774 hasConceptScore W1569090774C94412978 @default.
• W1569090774 hasIssue "12" @default.
• W1569090774 hasLocation W15690907741 @default.
• W1569090774 hasOpenAccess W1569090774 @default.
• W1569090774 hasPrimaryLocation W15690907741 @default.
• W1569090774 hasRelatedWork W1554222083 @default.
• W1569090774 hasRelatedWork W1569090774 @default.
• W1569090774 hasRelatedWork W1987966970 @default.
• W1569090774 hasRelatedWork W1989539984 @default.
• W1569090774 hasRelatedWork W2011589090 @default.
• W1569090774 hasRelatedWork W2161924525 @default.
• W1569090774 hasRelatedWork W2162798051 @default.
• W1569090774 hasRelatedWork W2319515459 @default.
• W1569090774 hasRelatedWork W4212847475 @default.
• W1569090774 hasRelatedWork W50361785 @default.
• W1569090774 hasVolume "242" @default.
• W1569090774 isParatext "false" @default.
• W1569090774 isRetracted "false" @default.
• W1569090774 magId "1569090774" @default.
• W1569090774 workType "article" @default.