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• W1569092261 abstract "Large intersubject variabilities in acoustic injury are known to occur in both humans and animals; however, the mechanisms underlying such differences are poorly understood. The olivocochlear efferent system has been hypothesized to play a significant role in protecting the cochlea from noise overexposure. In this study, we demonstrate that a newly developed test for determining average efferent system strength can predict intersubject variations in acoustic injury. In addition, the intersubject variability in cochlear expression of the α9 subunit of the nicotinic acetylcholine receptor was found to be proportional to an animals average efferent strength. Therefore, the inter-animal variability in the α9-containing acetylcholine receptor expression may be one mechanism contributing to the inter-animal variability in acoustic injury." @default.
• W1569092261 created "2016-06-24" @default.
• W1569092261 creator A5066244482 @default.
• W1569092261 creator A5085038387 @default.
• W1569092261 date "2002-05-15" @default.
• W1569092261 modified "2023-10-17" @default.
• W1569092261 title "Variation in Inter-Animal Susceptibility to Noise Damage Is Associated with α9 Acetylcholine Receptor Subunit Expression Level" @default.
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• W1569092261 doi "https://doi.org/10.1523/jneurosci.22-10-04241.2002" @default.
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