FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569093478> ?p ?o ?g. }

• W1569093478 endingPage "3429" @default.
• W1569093478 startingPage "3423" @default.
• W1569093478 abstract "Abstract The stimulatory effects of epinephrine, glucagon, and adrenocorticotropin (ACTH) upon lipolysis and on the uptake and oxidation of glucose were studied in isolated rat epididymal adipocytes. Under conditions in which prostaglandin E1 (PGE1) and nicotinic acid were antilipolytic against epinephrine, these agents were without influence on the effects of the hormone on the metabolism of glucose. Furthermore, the synergistic effects of caffeine and theophylline on epinephrine-induced lipolysis were not seen in studies of epinephrine-stimulated glucose oxidation. Since epinephrine increased the uptake and oxidation of glucose under conditions which either did (presence of bovine serum albumin) or did not (absence of bovine serum albumin) permit accumulation of free fatty acids, it is unlikely that free fatty acids mediate the effects of epinephrine on glucose entry and oxidation in adipocytes. Since two β-adrenergic blocking agents, Ko 592 and propranolol, inhibited epinephrine's stimulation of both lipolysis and glucose oxidation, it appears that both effects of the hormone involve β-receptors. While PGE1, Ko 592, and propranolol all inhibited the stimulatory effects of glucagon and ACTH on lipolysis in adipocytes, neither agent influenced the action of either hormone on glucose oxidation; the latter finding suggests that β-receptors do not mediate the stimulatory effects of these hormones on glucose oxidation. Ko 592 and propranolol were several orders of magnitude more potent as antilipolytic agents against epinephrine than they were against ACTH and glucagon. Excessive amounts of PGE1 only partially inhibited the lipolytic effect of even submaximal concentrations of epinephrine, glucagon, and ACTH in adipocytes, although total inhibitions were obtainable with appropriate concentrations of the β-adrenergic blocking compounds. Such observations suggest that the adenyl cyclase system for the synthesis of adenosine 3',5'-cyclic monophosphate in adipocytes contains at least two different types of activation receptor sites for hormones, and that PGE1 binds to only one type of site while the β-adrenergic blockers are effective against both types. The present, and previous, data permit the conclusion that epinephrine, ACTH, and glucagon stimulate the entry and over-all oxidation of glucose in adipocytes by a mechanism which is distinct from that (or those) by which these hormones promote lipolysis." @default.
• W1569093478 created "2016-06-24" @default.
• W1569093478 creator A5000271988 @default.
• W1569093478 creator A5044109013 @default.
• W1569093478 creator A5045621967 @default.
• W1569093478 creator A5046507014 @default.
• W1569093478 date "1969-07-01" @default.
• W1569093478 modified "2023-10-07" @default.
• W1569093478 title "Independence of the Effects of Epinephrine, Glucagon, and Adrenocorticotropin on Glucose Utilization from Those on Lipolysis in Isolated Rat Adipose Cells" @default.
• W1569093478 cites W107586950 @default.
• W1569093478 cites W125551675 @default.
• W1569093478 cites W145951705 @default.
• W1569093478 cites W1483105549 @default.
• W1569093478 cites W1536730092 @default.
• W1569093478 cites W1561824493 @default.
• W1569093478 cites W1570964021 @default.
• W1569093478 cites W1582996069 @default.
• W1569093478 cites W1601102460 @default.
• W1569093478 cites W1861973076 @default.
• W1569093478 cites W1968212942 @default.
• W1569093478 cites W1969637582 @default.
• W1569093478 cites W1979082907 @default.
• W1569093478 cites W1987657681 @default.
• W1569093478 cites W1991218053 @default.
• W1569093478 cites W1995123485 @default.
• W1569093478 cites W1998120531 @default.
• W1569093478 cites W2011675068 @default.
• W1569093478 cites W2022529471 @default.
• W1569093478 cites W20340857 @default.
• W1569093478 cites W2041113695 @default.
• W1569093478 cites W2046252532 @default.
• W1569093478 cites W2053522718 @default.
• W1569093478 cites W2057529735 @default.
• W1569093478 cites W2060474532 @default.
• W1569093478 cites W2072176729 @default.
• W1569093478 cites W2076313923 @default.
• W1569093478 cites W2112918293 @default.
• W1569093478 cites W2121446396 @default.
• W1569093478 cites W2143873575 @default.
• W1569093478 cites W2144909773 @default.
• W1569093478 cites W2165099278 @default.
• W1569093478 cites W2183717694 @default.
• W1569093478 cites W2185623874 @default.
• W1569093478 cites W2343200331 @default.
• W1569093478 cites W2419140929 @default.
• W1569093478 cites W4252279173 @default.
• W1569093478 doi "https://doi.org/10.1016/s0021-9258(18)83389-0" @default.
• W1569093478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4307449" @default.
• W1569093478 hasPublicationYear "1969" @default.
• W1569093478 type Work @default.
• W1569093478 sameAs 1569093478 @default.
• W1569093478 citedByCount "54" @default.
• W1569093478 countsByYear W15690934782014 @default.
• W1569093478 countsByYear W15690934782017 @default.
• W1569093478 countsByYear W15690934782018 @default.
• W1569093478 countsByYear W15690934782020 @default.
• W1569093478 crossrefType "journal-article" @default.
• W1569093478 hasAuthorship W1569093478A5000271988 @default.
• W1569093478 hasAuthorship W1569093478A5044109013 @default.
• W1569093478 hasAuthorship W1569093478A5045621967 @default.
• W1569093478 hasAuthorship W1569093478A5046507014 @default.
• W1569093478 hasBestOaLocation W15690934781 @default.
• W1569093478 hasConcept C105795698 @default.
• W1569093478 hasConcept C126322002 @default.
• W1569093478 hasConcept C134018914 @default.
• W1569093478 hasConcept C140985366 @default.
• W1569093478 hasConcept C171089720 @default.
• W1569093478 hasConcept C185592680 @default.
• W1569093478 hasConcept C2775859304 @default.
• W1569093478 hasConcept C2778563252 @default.
• W1569093478 hasConcept C2779306644 @default.
• W1569093478 hasConcept C33923547 @default.
• W1569093478 hasConcept C35651441 @default.
• W1569093478 hasConcept C71924100 @default.
• W1569093478 hasConceptScore W1569093478C105795698 @default.
• W1569093478 hasConceptScore W1569093478C126322002 @default.
• W1569093478 hasConceptScore W1569093478C134018914 @default.
• W1569093478 hasConceptScore W1569093478C140985366 @default.
• W1569093478 hasConceptScore W1569093478C171089720 @default.
• W1569093478 hasConceptScore W1569093478C185592680 @default.
• W1569093478 hasConceptScore W1569093478C2775859304 @default.
• W1569093478 hasConceptScore W1569093478C2778563252 @default.
• W1569093478 hasConceptScore W1569093478C2779306644 @default.
• W1569093478 hasConceptScore W1569093478C33923547 @default.
• W1569093478 hasConceptScore W1569093478C35651441 @default.
• W1569093478 hasConceptScore W1569093478C71924100 @default.
• W1569093478 hasIssue "13" @default.
• W1569093478 hasLocation W15690934781 @default.
• W1569093478 hasOpenAccess W1569093478 @default.
• W1569093478 hasPrimaryLocation W15690934781 @default.
• W1569093478 hasRelatedWork W1964688190 @default.
• W1569093478 hasRelatedWork W1978037308 @default.
• W1569093478 hasRelatedWork W2004449713 @default.
• W1569093478 hasRelatedWork W2026413826 @default.
• W1569093478 hasRelatedWork W2052848743 @default.
• W1569093478 hasRelatedWork W2145722810 @default.
• W1569093478 hasRelatedWork W2205422880 @default.
• W1569093478 hasRelatedWork W2460584456 @default.

• next