Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569097370> ?p ?o ?g. }
- W1569097370 endingPage "326" @default.
- W1569097370 startingPage "320" @default.
- W1569097370 abstract "Intralesional immunotherapy of melanoma has two complementary aims. One is to cause regression of the injected metastasis. The other is to incite or modulate systemic immune responses in such a way that non-injected metastases will also undergo regression. A number of phase 1 and phase II studies with cytokines, viral, or bacterial agents have been conducted but their use has remained sporadic and has not progressed to become established treatments. Two treatments have progressed to randomized phase III studies. The most promising of these is based on intralesional injection of a genetically modified herpes simplex virus (HSV) (T-Vec). Initial results have shown a significant effect on durable response rates (DRR) but effects on overall survival remain under study. The second involved injection of plasmids coding for the HLA B7 antigen (Allovectin). Despite encouraging early results the treatment did not reach its endpoints and its use has been discontinued. A phase II study involving intralesional injection of oncolytic A21 coxsackie virus (Cavatak) is also under way and is showing promise. J. Surg. Oncol. 2014 109:320–326. © 2013 Wiley Periodicals, Inc." @default.
- W1569097370 created "2016-06-24" @default.
- W1569097370 creator A5014685459 @default.
- W1569097370 creator A5055038393 @default.
- W1569097370 date "2013-12-03" @default.
- W1569097370 modified "2023-10-16" @default.
- W1569097370 title "Intralesional immunotherapy for melanoma" @default.
- W1569097370 cites W1551579334 @default.
- W1569097370 cites W1940683089 @default.
- W1569097370 cites W1974407768 @default.
- W1569097370 cites W1976041409 @default.
- W1569097370 cites W2006521968 @default.
- W1569097370 cites W2011653164 @default.
- W1569097370 cites W2011852843 @default.
- W1569097370 cites W2028894516 @default.
- W1569097370 cites W2034841659 @default.
- W1569097370 cites W2050271506 @default.
- W1569097370 cites W2051302288 @default.
- W1569097370 cites W2051940153 @default.
- W1569097370 cites W2057577614 @default.
- W1569097370 cites W2073277368 @default.
- W1569097370 cites W2082150850 @default.
- W1569097370 cites W2085787008 @default.
- W1569097370 cites W2086400790 @default.
- W1569097370 cites W2087680655 @default.
- W1569097370 cites W2089228335 @default.
- W1569097370 cites W2090332169 @default.
- W1569097370 cites W2097849707 @default.
- W1569097370 cites W2097995306 @default.
- W1569097370 cites W2099648846 @default.
- W1569097370 cites W2100158834 @default.
- W1569097370 cites W2102557111 @default.
- W1569097370 cites W2103675014 @default.
- W1569097370 cites W2105747169 @default.
- W1569097370 cites W2114903025 @default.
- W1569097370 cites W2118982164 @default.
- W1569097370 cites W2123363005 @default.
- W1569097370 cites W2128542677 @default.
- W1569097370 cites W2136443494 @default.
- W1569097370 cites W2143163879 @default.
- W1569097370 cites W2156078931 @default.
- W1569097370 cites W2158157784 @default.
- W1569097370 cites W2160834915 @default.
- W1569097370 cites W2964072928 @default.
- W1569097370 cites W4211238487 @default.
- W1569097370 cites W4235729974 @default.
- W1569097370 cites W4253765578 @default.
- W1569097370 doi "https://doi.org/10.1002/jso.23494" @default.
- W1569097370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24301265" @default.
- W1569097370 hasPublicationYear "2013" @default.
- W1569097370 type Work @default.
- W1569097370 sameAs 1569097370 @default.
- W1569097370 citedByCount "54" @default.
- W1569097370 countsByYear W15690973702013 @default.
- W1569097370 countsByYear W15690973702014 @default.
- W1569097370 countsByYear W15690973702015 @default.
- W1569097370 countsByYear W15690973702016 @default.
- W1569097370 countsByYear W15690973702017 @default.
- W1569097370 countsByYear W15690973702018 @default.
- W1569097370 countsByYear W15690973702019 @default.
- W1569097370 countsByYear W15690973702020 @default.
- W1569097370 countsByYear W15690973702021 @default.
- W1569097370 countsByYear W15690973702022 @default.
- W1569097370 countsByYear W15690973702023 @default.
- W1569097370 crossrefType "journal-article" @default.
- W1569097370 hasAuthorship W1569097370A5014685459 @default.
- W1569097370 hasAuthorship W1569097370A5055038393 @default.
- W1569097370 hasConcept C126322002 @default.
- W1569097370 hasConcept C141071460 @default.
- W1569097370 hasConcept C143998085 @default.
- W1569097370 hasConcept C203014093 @default.
- W1569097370 hasConcept C2522874641 @default.
- W1569097370 hasConcept C2777658100 @default.
- W1569097370 hasConcept C2777701055 @default.
- W1569097370 hasConcept C2781196997 @default.
- W1569097370 hasConcept C502942594 @default.
- W1569097370 hasConcept C71924100 @default.
- W1569097370 hasConcept C82210918 @default.
- W1569097370 hasConcept C8891405 @default.
- W1569097370 hasConceptScore W1569097370C126322002 @default.
- W1569097370 hasConceptScore W1569097370C141071460 @default.
- W1569097370 hasConceptScore W1569097370C143998085 @default.
- W1569097370 hasConceptScore W1569097370C203014093 @default.
- W1569097370 hasConceptScore W1569097370C2522874641 @default.
- W1569097370 hasConceptScore W1569097370C2777658100 @default.
- W1569097370 hasConceptScore W1569097370C2777701055 @default.
- W1569097370 hasConceptScore W1569097370C2781196997 @default.
- W1569097370 hasConceptScore W1569097370C502942594 @default.
- W1569097370 hasConceptScore W1569097370C71924100 @default.
- W1569097370 hasConceptScore W1569097370C82210918 @default.
- W1569097370 hasConceptScore W1569097370C8891405 @default.
- W1569097370 hasIssue "4" @default.
- W1569097370 hasLocation W15690973701 @default.
- W1569097370 hasLocation W15690973702 @default.
- W1569097370 hasOpenAccess W1569097370 @default.
- W1569097370 hasPrimaryLocation W15690973701 @default.
- W1569097370 hasRelatedWork W198294540 @default.
- W1569097370 hasRelatedWork W1995029154 @default.