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• W1569112678 abstract "Natural IgM has a wide range of actions in the immune system. Here we demonstrate that mice lacking serum IgM have an expansion in splenic marginal zone B cells with a proportionately smaller reduction in follicular B cells. The increase in the marginal zone-follicular B cell ratio (and an expansion in peritoneal B1a cells) is fully reversed by administration of polyclonal IgM, but not by two IgM monoclonals. Mice engineered to have a secreted oligoclonal IgM repertoire with an endogenous membrane IgM also exhibited a similar expansion of marginal zone B cells. We propose that natural IgM, by virtue of its polyreactivity, enhances Ag-driven signaling through the B cell receptor and promotes the formation of follicular B cells. These results demonstrate that natural IgM regulates the selection of B lymphocyte subsets." @default.
• W1569112678 created "2016-06-24" @default.
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• W1569112678 date "2002-12-15" @default.
• W1569112678 modified "2023-09-26" @default.
• W1569112678 title "Cutting Edge: Selection of B Lymphocyte Subsets Is Regulated by Natural IgM" @default.
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• W1569112678 doi "https://doi.org/10.4049/jimmunol.169.12.6686" @default.
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